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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Comparative Venomics Reveals the Complex Prey Capture Strategy of the Piscivorous Cone Snail Conus catus
|
|---|---|
| Published in |
Journal of Proteome Research, September 2015
|
| DOI | 10.1021/acs.jproteome.5b00630 |
| Pubmed ID | |
| Authors |
S W A Himaya, Ai-Hua Jin, Sébastien Dutertre, Jean Giacomotto, Hoshyar Mohialdeen, Irina Vetter, Paul F Alewood, Richard J Lewis |
| Abstract |
Venomous marine cone snails produce a unique and remarkably diverse range of venom peptides (conotoxins and conopeptides) that have proven invaluable as pharmacological probes and leads to new therapies. Conus catus is 'hook-and-line' fish hunter from clade I, with ~20 conotoxins identified, including the analgesic ω-conotoxin CVID (AM336). The current study unravels the venom composition of C. catus with tandem mass spectrometry and 454 sequencing data. From the venom gland transcriptome, 104 precursors were recovered from 11 superfamilies, with superfamily A (especially κA-) conotoxins dominating (77%) their venom. Proteomic analysis confirmed the κA-conotoxins dominated the predation-evoked milked venom of each of six C. catus analysed and revealed remarkable intraspecific variation in both the intensity and type of conotoxins. High-throughput FLIPR assays revealed that the predation-evoked venom contained a range of conotoxins targeting the nAChR, Cav and Nav ion channels, consistent with α- and ω-conotoxins being used for predation by C. catus. However, the κA-conotoxins did not act at these targets but induced potent and rapid immobilisation followed by bursts of activity and finally paralysis when injected intramuscularly in zebrafish. Our venomics approach revealed the complexity of the envenomation strategy used by C. catus, which contains a mix of both excitatory and inhibitory venom peptides. |
X Demographics
The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 1 | 25% |
| Unknown | 3 | 75% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 41 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 2% |
| Unknown | 40 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 8 | 20% |
| Student > Bachelor | 5 | 12% |
| Student > Master | 5 | 12% |
| Student > Ph. D. Student | 4 | 10% |
| Student > Doctoral Student | 2 | 5% |
| Other | 4 | 10% |
| Unknown | 13 | 32% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 9 | 22% |
| Biochemistry, Genetics and Molecular Biology | 9 | 22% |
| Pharmacology, Toxicology and Pharmaceutical Science | 3 | 7% |
| Chemistry | 3 | 7% |
| Sports and Recreations | 1 | 2% |
| Other | 1 | 2% |
| Unknown | 15 | 37% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 September 2015.
All research outputs
#14,824,070
of 22,826,360 outputs
Outputs from Journal of Proteome Research
#4,225
of 6,025 outputs
Outputs of similar age
#147,484
of 267,231 outputs
Outputs of similar age from Journal of Proteome Research
#50
of 128 outputs
Altmetric has tracked 22,826,360 research outputs across all sources so far. This one is in the 32nd percentile – i.e., 32% of other outputs scored the same or lower than it.
So far Altmetric has tracked 6,025 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.2. This one is in the 26th percentile – i.e., 26% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 267,231 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 41st percentile – i.e., 41% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 128 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 53% of its contemporaries.