| Title |
Signatures of miR-181a on the Renal Transcriptome and Blood Pressure
|
|---|---|
| Published in |
Molecular Medicine, August 2015
|
| DOI | 10.2119/molmed.2015.00096 |
| Pubmed ID | |
| Authors |
Francine Z. Marques, Simon P. R. Romaine, Matthew Denniff, James Eales, John Dormer, Ingrid M. Garrelds, Lukasz Wojnar, Katarzyna Musialik, Barbara Duda-Raszewska, Bartlomiej Kiszka, Magdalena Duda, Brian J. Morris, Nilesh J. Samani, A. H. Jan Danser, Pawel Bogdanski, Ewa Zukowska-Szczechowska, Fadi J. Charchar, Maciej Tomaszewski |
| Abstract |
MicroRNA-181a binds to the 3' untranslated region of messenger RNA (mRNA) for renin, a rate-limiting enzyme of the renin-angiotensin system. Our objective was to determine whether this molecular interaction translates into a clinically meaningful effect on blood pressure and whether circulating miR-181a is a measurable proxy of blood pressure. In 200 human kidneys from the TRANScriptome of renaL humAn TissuE (TRANSLATE) Study, renal miR-181a was the sole negative predictor of renin mRNA and a strong correlate of circulating miR-181a. Elevated miR-181a levels correlated positively with systolic and diastolic blood pressure in TRANSLATE, and this association was independent of circulating renin. The association between serum miR-181a and systolic blood pressure was replicated in 199 subjects from the Genetic Regulation of Arterial Pressure of Humans In the Community (GRAPHIC) Study. Renal immunohistochemistry and in situ hybridization showed that co-localization of miR-181a and renin was most prominent in collecting ducts from where renin is not released into the systemic circulation. Analysis of 69 human kidneys characterized by RNA-sequencing revealed that miR-181a was associated with down-regulation of four mitochondrial pathways and up-regulation of 41 signalling cascades of adaptive immunity and inflammation. We conclude that renal miR-181a has pleiotropic effects on pathways relevant to blood pressure regulation and that circulating levels of miR-181a are both a measurable proxy of renal miR-181a expression and a novel biochemical correlate of blood pressure. |
X Demographics
The data shown below were collected from the profiles of 8 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Canada | 1 | 13% |
| United States | 1 | 13% |
| Curaçao | 1 | 13% |
| Unknown | 5 | 63% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 5 | 63% |
| Scientists | 2 | 25% |
| Science communicators (journalists, bloggers, editors) | 1 | 13% |
Mendeley readers
The data shown below were compiled from readership statistics for 28 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 28 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 7 | 25% |
| Student > Ph. D. Student | 5 | 18% |
| Other | 2 | 7% |
| Researcher | 2 | 7% |
| Professor | 2 | 7% |
| Other | 4 | 14% |
| Unknown | 6 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 9 | 32% |
| Medicine and Dentistry | 6 | 21% |
| Nursing and Health Professions | 3 | 11% |
| Agricultural and Biological Sciences | 1 | 4% |
| Neuroscience | 1 | 4% |
| Other | 0 | 0% |
| Unknown | 8 | 29% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 March 2023.
All research outputs
#7,025,440
of 24,452,844 outputs
Outputs from Molecular Medicine
#333
of 1,228 outputs
Outputs of similar age
#78,235
of 272,075 outputs
Outputs of similar age from Molecular Medicine
#2
of 11 outputs
Altmetric has tracked 24,452,844 research outputs across all sources so far. This one has received more attention than most of these and is in the 69th percentile.
So far Altmetric has tracked 1,228 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.3. This one has gotten more attention than average, scoring higher than 71% of its peers.
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We're also able to compare this research output to 11 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 81% of its contemporaries.