| Title |
Clinical Research on Alzheimer’s Disease: Progress and Perspectives
|
|---|---|
| Published in |
Neuroscience Bulletin, June 2018
|
| DOI | 10.1007/s12264-018-0249-z |
| Pubmed ID | |
| Authors |
Bin-Lu Sun, Wei-Wei Li, Chi Zhu, Wang-Sheng Jin, Fan Zeng, Yu-Hui Liu, Xian-Le Bu, Jie Zhu, Xiu-Qing Yao, Yan-Jiang Wang |
| Abstract |
Alzheimer's disease (AD), the most common type of dementia, is becoming a major challenge for global health and social care. However, the current understanding of AD pathogenesis is limited, and no early diagnosis and disease-modifying therapy are currently available. During the past year, significant progress has been made in clinical research on the diagnosis, prevention, and treatment of AD. In this review, we summarize the latest achievements, including diagnostic biomarkers, polygenic hazard score, amyloid and tau PET imaging, clinical trials targeting amyloid-beta (Aβ), tau, and neurotransmitters, early intervention, and primary prevention and systemic intervention approaches, and provide novel perspectives for further efforts to understand and cure the disease. |
Mendeley readers
The data shown below were compiled from readership statistics for 197 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 197 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 25 | 13% |
| Student > Master | 19 | 10% |
| Student > Ph. D. Student | 18 | 9% |
| Researcher | 15 | 8% |
| Student > Postgraduate | 9 | 5% |
| Other | 20 | 10% |
| Unknown | 91 | 46% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 22 | 11% |
| Medicine and Dentistry | 19 | 10% |
| Biochemistry, Genetics and Molecular Biology | 12 | 6% |
| Pharmacology, Toxicology and Pharmaceutical Science | 12 | 6% |
| Nursing and Health Professions | 6 | 3% |
| Other | 30 | 15% |
| Unknown | 96 | 49% |
Attention Score in Context
This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 July 2018.
All research outputs
#4,241,512
of 23,094,276 outputs
Outputs from Neuroscience Bulletin
#135
of 787 outputs
Outputs of similar age
#82,403
of 329,256 outputs
Outputs of similar age from Neuroscience Bulletin
#3
of 18 outputs
Altmetric has tracked 23,094,276 research outputs across all sources so far. Compared to these this one has done well and is in the 80th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 787 research outputs from this source. They receive a mean Attention Score of 3.9. This one has done well, scoring higher than 78% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 329,256 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 73% of its contemporaries.
We're also able to compare this research output to 18 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.