| Title |
Effects of Zinc Supplementation on Endocrine Outcomes in Women with Polycystic Ovary Syndrome: a Randomized, Double-Blind, Placebo-Controlled Trial
|
|---|---|
| Published in |
Biological Trace Element Research, August 2015
|
| DOI | 10.1007/s12011-015-0480-7 |
| Pubmed ID | |
| Authors |
Mehri Jamilian, Fatemeh Foroozanfard, Fereshteh Bahmani, Rezvan Talaee, Mahshid Monavari, Zatollah Asemi |
| Abstract |
The current study was conducted to evaluate the effects of zinc supplementation on endocrine outcomes, biomarkers of inflammation, and oxidative stress in patients with polycystic ovary syndrome (PCOS). This study was a randomized double-blind, placebo-controlled trial. Forty-eight women (18-40 years) with PCOS diagnosed according to Rotterdam criteria were randomly assigned to receive either 220 mg zinc sulfate (containing 50 mg zinc) (group 1; n = 24) and/or placebo (group 2; n = 24) for 8 weeks. Hormonal profiles, biomarkers of inflammation, and oxidative stress were measured at study baseline and after 8-week intervention. After 8 weeks of intervention, alopecia (41.7 vs. 12.5 %, P = 0.02) decreased compared with the placebo. Additionally, patients who received zinc supplements had significantly decreased hirsutism (modified Ferriman-Gallwey scores) (-1.71 ± 0.99 vs. -0.29 ± 0.95, P < 0.001) and plasma malondialdehyde (MDA) levels (-0.09 ± 1.31 vs. +2.34 ± 5.53 μmol/L, P = 0.04) compared with the placebo. A trend toward a significant effect of zinc intake on reducing high-sensitivity C-reactive protein (hs-CRP) levels (P = 0.06) was also observed. We did observe no significant changes of zinc supplementation on hormonal profiles, inflammatory cytokines, and other biomarkers of oxidative stress. In conclusion, using 50 mg/day elemental zinc for 8 weeks among PCOS women had beneficial effects on alopecia, hirsutism, and plasma MDA levels; however, it did not affect hormonal profiles, inflammatory cytokines, and other biomarkers of oxidative stress. |
X Demographics
The data shown below were collected from the profiles of 16 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 4 | 25% |
| Canada | 2 | 13% |
| Kuwait | 1 | 6% |
| Saudi Arabia | 1 | 6% |
| Greece | 1 | 6% |
| India | 1 | 6% |
| Belgium | 1 | 6% |
| New Zealand | 1 | 6% |
| Unknown | 4 | 25% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 11 | 69% |
| Scientists | 2 | 13% |
| Practitioners (doctors, other healthcare professionals) | 2 | 13% |
| Science communicators (journalists, bloggers, editors) | 1 | 6% |
Mendeley readers
The data shown below were compiled from readership statistics for 146 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 146 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 40 | 27% |
| Researcher | 15 | 10% |
| Student > Master | 11 | 8% |
| Student > Ph. D. Student | 10 | 7% |
| Student > Postgraduate | 8 | 5% |
| Other | 23 | 16% |
| Unknown | 39 | 27% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 48 | 33% |
| Nursing and Health Professions | 21 | 14% |
| Biochemistry, Genetics and Molecular Biology | 10 | 7% |
| Agricultural and Biological Sciences | 6 | 4% |
| Unspecified | 6 | 4% |
| Other | 15 | 10% |
| Unknown | 40 | 27% |
Attention Score in Context
This research output has an Altmetric Attention Score of 36. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 January 2024.
All research outputs
#1,113,321
of 25,200,621 outputs
Outputs from Biological Trace Element Research
#46
of 2,268 outputs
Outputs of similar age
#14,805
of 274,299 outputs
Outputs of similar age from Biological Trace Element Research
#3
of 24 outputs
Altmetric has tracked 25,200,621 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,268 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.3. This one has done particularly well, scoring higher than 98% of its peers.
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We're also able to compare this research output to 24 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 91% of its contemporaries.