Title |
Quality of life after early enteral feeding versus standard care for proven or suspected advanced epithelial ovarian cancer: Results from a randomised trial
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Published in |
Gynecologic Oncology, March 2015
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DOI | 10.1016/j.ygyno.2015.03.048 |
Pubmed ID | |
Authors |
Jannah Baker, Monika Janda, Nick Graves, Judy Bauer, Merrilyn Banks, Andrea Garrett, Naven Chetty, Alex J. Crandon, Russell Land, Marcelo Nascimento, James L. Nicklin, Lewis C. Perrin, Andreas Obermair |
Abstract |
Malnutrition is common in patients with advanced Epithelial Ovarian Cancer (EOC), and is associated with impaired quality of life (QoL), longer hospital stay and higher risk of treatment-related adverse events. This phase III multi-centre randomised clinical trial tested early enteral feeding versus standard care on postoperative QoL. From 2009-2013, 109 patients requiring surgery for suspected advanced EOC, moderately to severely malnourished were enrolled at five sites across Queensland and randomised to intervention (n=53) or control (n=56) groups. Intervention involved intraoperative nasojejunal tube placement and enteral feeding until adequate oral intake could be maintained. Despite being randomised to intervention, 20 patients did not receive feeds (13 did not receive the feeding tube; 7 had it removed early). Control involved postoperative diet as tolerated. QoL was measured at baseline, 6 weeks postoperatively and 30 days after the third cycle of chemotherapy. The primary outcome measure was difference in QoL between intervention and control group. Secondary endpoints included treatment-related adverse event occurrence, length of stay, postoperative services use, and nutritional status. Baseline characteristics were comparable between treatment groups. No significant difference in QoL was found between the groups at any timepoint. There was a trend towards better nutritional status in patients who received the intervention but the differences did not reach statistical significance except for the intention-to-treat analysis at 7 days postoperatively (11.8 intervention vs. 13.8 control, p 0.04). Early enteral feeding did not significantly improve patients' QoL compared to standard of care but may improve nutritional status. Cancer Australia project grant 631524. |
X Demographics
Geographical breakdown
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Australia | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 93 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 18 | 19% |
Student > Bachelor | 9 | 10% |
Other | 8 | 9% |
Researcher | 7 | 8% |
Student > Postgraduate | 6 | 6% |
Other | 16 | 17% |
Unknown | 29 | 31% |
Readers by discipline | Count | As % |
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Nursing and Health Professions | 25 | 27% |
Medicine and Dentistry | 24 | 26% |
Biochemistry, Genetics and Molecular Biology | 4 | 4% |
Social Sciences | 3 | 3% |
Sports and Recreations | 2 | 2% |
Other | 3 | 3% |
Unknown | 32 | 34% |