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Crossroads Between Innate and Adaptive Immunity V

Overview of attention for book
Attention for Chapter 5: Selective Dependence of Kidney Dendritic Cells on CX3CR1-Implications for Glomerulonephritis Therapy.
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Chapter title
Selective Dependence of Kidney Dendritic Cells on CX3CR1-Implications for Glomerulonephritis Therapy.
Chapter number 5
Book title
Crossroads Between Innate and Adaptive Immunity V
Published in
Advances in experimental medicine and biology, January 2015
DOI 10.1007/978-3-319-15774-0_5
Pubmed ID
Book ISBNs
978-3-31-915773-3, 978-3-31-915774-0
Authors

Hochheiser, Katharina, Kurts, Christian, Katharina Hochheiser, Christian Kurts

Abstract

As central regulators of the adaptive immune response, dendritic cells (DCs) are found in virtually all lymphatic and non-lymphatic organs. A compact network of DCs also spans the kidneys. DCs play a central role in maintenance of organ homeostasis as well as in induction of immune responses against invading pathogens. They can mediate protective or destructive functions in a context-dependent manner.We recently identified CX3CR1 as a kidney-specific "homing receptor" for DCs. There was a strong reduction of DCs in the kidneys of CX3CR1-deficient mice compared to controls. This reduction was not observed in other organs except the small intestine. As a possible underlying reason we found a strong expression of the CX3CR1 ligand fractalkine in the kidneys. Due to this CX3CR1-dependent reduction of DCs, especially in the renal cortex, a glomerulonephritis (GN) model was ameliorated in CX3CR1-deficient mice. In contrast, the immune defense against the most common renal infection, bacterial pyelonephritis (PN), was not significantly influenced by CX3CR1-deficiency. This was explained by the much smaller CX3CR1-dependency of medullary DCs, which recruit effector cells into the kidney during PN. Additionally, once neutrophils had been recruited by mechanisms distinct from CX3CR1, they carried out some of the functions of DCs.Taken together, we suggest CX3CR1 as a therapeutic target for GN treatment, as the absence of CX3CR1 selectively influences DCs in the kidney without rendering mice more susceptible towards bacterial kidney infections.

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Geographical breakdown

Country Count As %
United States 1 20%
Unknown 4 80%

Demographic breakdown

Readers by professional status Count As %
Librarian 1 20%
Lecturer 1 20%
Student > Doctoral Student 1 20%
Professor 1 20%
Researcher 1 20%
Other 0 0%
Readers by discipline Count As %
Agricultural and Biological Sciences 2 40%
Veterinary Science and Veterinary Medicine 1 20%
Nursing and Health Professions 1 20%
Medicine and Dentistry 1 20%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 September 2015.
All research outputs
#15,345,593
of 22,826,360 outputs
Outputs from Advances in experimental medicine and biology
#2,503
of 4,950 outputs
Outputs of similar age
#209,013
of 353,136 outputs
Outputs of similar age from Advances in experimental medicine and biology
#119
of 272 outputs
Altmetric has tracked 22,826,360 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,950 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.0. This one is in the 37th percentile – i.e., 37% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 353,136 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 31st percentile – i.e., 31% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 272 others from the same source and published within six weeks on either side of this one. This one is in the 43rd percentile – i.e., 43% of its contemporaries scored the same or lower than it.