| Title |
Acoustophoretic removal of proteins from blood components
|
|---|---|
| Published in |
Biomedical Microdevices, August 2015
|
| DOI | 10.1007/s10544-015-0003-5 |
| Pubmed ID | |
| Authors |
Maria Tenje, Maria N. Lundgren, Ann-Margret Swärd-Nilsson, Jens Kjeldsen-Kragh, Lena Lyxe, Andreas Lenshof |
| Abstract |
This work presents the development of a miniaturized system for removing plasma proteins and other low-molecular-weight compounds from red blood cell (RBC) concentrate in a simple one-step-process using integrated ultrasound. The technology utilizes the principles of acoustophoresis to transfer the RBCs from the original plasma-containing solution into a protein-free SAG-M additive solution in a continuous flow process. The preparation of protein free RBC concentrate is important for blood transfusion to patients suffering from immunoglobulin A (IgA)-deficiency and developing antibodies against IgA. We show a nearly complete removal of both albumin and IgA from concentrated RBCs via this one-step-processes in samples obtained from RBC concentrate. The cell recovery of our technology is close to 97 %, compared to just above 90 % of the current procedure of repeated dilution and centrifugation steps. This work clearly shows the potential of integrated acoustophoresis in a miniaturized system for clinical applications. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 28 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 7% |
| Unknown | 26 | 93% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 12 | 43% |
| Student > Bachelor | 4 | 14% |
| Student > Master | 4 | 14% |
| Student > Postgraduate | 2 | 7% |
| Professor | 1 | 4% |
| Other | 3 | 11% |
| Unknown | 2 | 7% |
| Readers by discipline | Count | As % |
|---|---|---|
| Engineering | 16 | 57% |
| Chemical Engineering | 2 | 7% |
| Materials Science | 2 | 7% |
| Social Sciences | 1 | 4% |
| Nursing and Health Professions | 1 | 4% |
| Other | 2 | 7% |
| Unknown | 4 | 14% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 September 2015.
All research outputs
#20,290,425
of 22,826,360 outputs
Outputs from Biomedical Microdevices
#666
of 747 outputs
Outputs of similar age
#224,086
of 266,764 outputs
Outputs of similar age from Biomedical Microdevices
#13
of 17 outputs
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