| Title |
Timeline (Bioavailability) of Magnesium Compounds in Hours: Which Magnesium Compound Works Best?
|
|---|---|
| Published in |
Biological Trace Element Research, April 2018
|
| DOI | 10.1007/s12011-018-1351-9 |
| Pubmed ID | |
| Authors |
Nazan Uysal, Servet Kizildag, Zeynep Yuce, Guven Guvendi, Sevim Kandis, Basar Koc, Aslı Karakilic, Ulas M. Camsari, Mehmet Ates |
| Abstract |
Magnesium is an element of great importance functioning because of its association with many cellular physiological functions. The magnesium content of foods is gradually decreasing due to food processing, and magnesium supplementation for healthy living has become increasingly popular. However, data is very limited on the bioavailability of various magnesium preparations. The aim of this study is to investigate the bioavailability of five different magnesium compounds (magnesium sulfate, magnesium oxide, magnesium acetyl taurate, magnesium citrate, and magnesium malate) in different tissues. Following a single dose 400 mg/70 kg magnesium administration to Sprague Dawley rats, bioavailability was evaluated by examining time-dependent absorption, tissue penetration, and the effects on the behavior of the animals. Pharmacokinetically, the area under the curve calculation is highest in the magnesium malate. The magnesium acetyl taurate was found to have the second highest area under the curve calculation. Magnesium acetyl taurate was rapidly absorbed, able to pass through to the brain easily, had the highest tissue concentration level in the brain, and was found to be associated with decreased anxiety indicators. Magnesium malate levels remained high for an extended period of time in the serum. The commonly prescribed dietary supplements magnesium oxide and magnesium citrate had the lowest bioavailability when compared to our control group. More research is needed to investigate the bioavailability of magnesium malate and acetyl taurate compounds and their effects in specific tissues and on behavior. |
X Demographics
The data shown below were collected from the profiles of 141 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 27 | 19% |
| United States | 10 | 7% |
| France | 3 | 2% |
| Germany | 3 | 2% |
| Austria | 1 | <1% |
| United Kingdom | 1 | <1% |
| Ecuador | 1 | <1% |
| Maldives | 1 | <1% |
| Panama | 1 | <1% |
| Other | 3 | 2% |
| Unknown | 90 | 64% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 126 | 89% |
| Scientists | 6 | 4% |
| Practitioners (doctors, other healthcare professionals) | 4 | 3% |
| Science communicators (journalists, bloggers, editors) | 3 | 2% |
| Unknown | 2 | 1% |
Mendeley readers
The data shown below were compiled from readership statistics for 146 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 146 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 22 | 15% |
| Student > Bachelor | 20 | 14% |
| Researcher | 14 | 10% |
| Student > Ph. D. Student | 12 | 8% |
| Other | 11 | 8% |
| Other | 16 | 11% |
| Unknown | 51 | 35% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 20 | 14% |
| Nursing and Health Professions | 18 | 12% |
| Agricultural and Biological Sciences | 13 | 9% |
| Biochemistry, Genetics and Molecular Biology | 11 | 8% |
| Pharmacology, Toxicology and Pharmaceutical Science | 5 | 3% |
| Other | 21 | 14% |
| Unknown | 58 | 40% |
Attention Score in Context
This research output has an Altmetric Attention Score of 151. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 April 2024.
All research outputs
#278,315
of 25,830,005 outputs
Outputs from Biological Trace Element Research
#10
of 2,356 outputs
Outputs of similar age
#6,235
of 341,759 outputs
Outputs of similar age from Biological Trace Element Research
#1
of 41 outputs
Altmetric has tracked 25,830,005 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,356 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.4. This one has done particularly well, scoring higher than 99% of its peers.
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We're also able to compare this research output to 41 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 97% of its contemporaries.