| Title |
SDF-1/CXCR4 axis modulates bone marrow mesenchymal stem cell apoptosis, migration and cytokine secretion
|
|---|---|
| Published in |
Protein & Cell, November 2011
|
| DOI | 10.1007/s13238-011-1097-z |
| Pubmed ID | |
| Authors |
Xiaolei Liu, Biyan Duan, Zhaokang Cheng, Xiaohua Jia, Lina Mao, Hao Fu, Yongzhe Che, Lailiang Ou, Lin Liu, Deling Kong |
| Abstract |
Bone marrow mesenchymal stem cells (MSCs) are considered as a promising cell source to treat the acute myocardial infarction. However, over 90% of the stem cells usually die in the first three days of transplantation. Survival potential, migration ability and paracrine capacity have been considered as the most important three factors for cell transplantation in the ischemic cardiac treatment. We hypothesized that stromal-derived factor-1 (SDF-1)/CXCR4 axis plays a critical role in the regulation of these processes. In this study, apoptosis was induced by exposure of MSCs to H(2)O(2) for 2 h. After re-oxygenation, the SDF-1 pretreated MSCs demonstrated a significant increase in survival and proliferation. SDF-1 pretreatment also enhanced the migration and increased the secretion of pro-survival and angiogenic cytokines including basic fibroblast growth factor and vascular endothelial growth factor. Western blot and RT-PCR demonstrated that SDF-1 pretreatment significantly activated the pro-survival Akt and Erk signaling pathways and up-regulated Bcl-2/Bax ratio. These protective effects were partially inhibited by AMD3100, an antagonist of CXCR4.We conclude that the SDF-1/CXCR4 axis is critical for MSC survival, migration and cytokine secretion. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 143 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | 1% |
| United States | 2 | 1% |
| Spain | 1 | <1% |
| Japan | 1 | <1% |
| Unknown | 137 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 29 | 20% |
| Researcher | 24 | 17% |
| Student > Master | 23 | 16% |
| Student > Bachelor | 11 | 8% |
| Student > Doctoral Student | 8 | 6% |
| Other | 26 | 18% |
| Unknown | 22 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 29 | 20% |
| Biochemistry, Genetics and Molecular Biology | 27 | 19% |
| Medicine and Dentistry | 27 | 19% |
| Engineering | 9 | 6% |
| Pharmacology, Toxicology and Pharmaceutical Science | 5 | 3% |
| Other | 17 | 12% |
| Unknown | 29 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 November 2011.
All research outputs
#20,150,151
of 22,656,971 outputs
Outputs from Protein & Cell
#659
of 736 outputs
Outputs of similar age
#130,101
of 141,898 outputs
Outputs of similar age from Protein & Cell
#11
of 11 outputs
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