| Title |
Dynamics of macrophage populations of the liver after subtotal hepatectomy in rats
|
|---|---|
| Published in |
BMC Immunology, July 2018
|
| DOI | 10.1186/s12865-018-0260-1 |
| Pubmed ID | |
| Authors |
Andrey V. Elchaninov, Timur Kh. Fatkhudinov, Natalia Y. Usman, Evgeniya Y. Kananykhina, Irina V. Arutyunyan, Andrey V. Makarov, Anastasia V. Lokhonina, Irina Z. Eremina, Viktor V. Surovtsev, Dmitry V. Goldshtein, Galina B. Bolshakova, Valeria V. Glinkina, Gennady T. Sukhikh |
| Abstract |
In many clinical cases of extensive liver resection (e.g. due to malignancy), the residual portion is too small to maintain the body homeostasis. The resulting acute liver failure is associated with the compensatory growth inhibition, which is a typical manifestation of the 'small for size' liver syndrome. The study investigates possible causes of the delayed onset of hepatocyte proliferation after subtotal hepatectomy (80% liver resection) in rats. The data indicate that the growth inhibition correlates with delayed upregulation of the Tnf gene expression and low content of the corresponding Tnfα protein within the residual hepatic tissue. Considering the involvement of Tnf/Tnfα, the observed growth inhibition may be related to particular properties of liver macrophages - the resident Kupffer cells with CD68+CX1CR3-CD11b- phenotype. The delayed onset of hepatocyte proliferation correlates with low levels of Tnfα in the residual hepatic tissue. The observed growth inhibition possibly reflects specific composition of macrophage population of the liver. It is entirely composed of embryonically-derived Kupffer cells, which express the 'proregeneratory' M2 macrophage-specific marker CD206 in the course of regeneration. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Science communicators (journalists, bloggers, editors) | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 26 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 26 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 5 | 19% |
| Student > Master | 4 | 15% |
| Other | 3 | 12% |
| Student > Bachelor | 3 | 12% |
| Student > Ph. D. Student | 2 | 8% |
| Other | 3 | 12% |
| Unknown | 6 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 6 | 23% |
| Medicine and Dentistry | 4 | 15% |
| Immunology and Microbiology | 3 | 12% |
| Agricultural and Biological Sciences | 2 | 8% |
| Nursing and Health Professions | 1 | 4% |
| Other | 2 | 8% |
| Unknown | 8 | 31% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 July 2018.
All research outputs
#18,641,800
of 23,094,276 outputs
Outputs from BMC Immunology
#428
of 590 outputs
Outputs of similar age
#252,186
of 326,642 outputs
Outputs of similar age from BMC Immunology
#10
of 13 outputs
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