| Title |
The DIAMOND trial – DIfferent Approaches to MOderate & late preterm Nutrition: Determinants of feed tolerance, body composition and development: protocol of a randomised trial
|
|---|---|
| Published in |
BMC Pediatrics, July 2018
|
| DOI | 10.1186/s12887-018-1195-7 |
| Pubmed ID | |
| Authors |
Frank H. Bloomfield, Jane E. Harding, Michael P. Meyer, Jane M. Alsweiler, Yannan Jiang, Clare R. Wall, Tanith Alexander, on behalf of the DIAMOND Study Group |
| Abstract |
Babies born at moderate-late preterm gestations account for > 80% of all preterm births. Although survival is excellent, these babies are at increased risk of adverse neurodevelopmental outcomes. They also are at increased risk of adverse long-term health outcomes, such as cardiovascular disease, obesity and diabetes. There is little evidence guiding optimal nutritional practices in these babies; practice, therefore, varies widely. This factorial design clinical trial will address the role of parenteral nutrition, milk supplementation and exposure of the preterm infant to taste and smell with each feed on time to tolerance of full feeds, adiposity, and neurodevelopment at 2 years. The DIAMOND trial is a multi-centre, factorial, randomised, controlled clinical trial. A total of 528 babies born between 32+ 0 and 35+ 6 weeks' gestation receiving intravenous fluids and whose mothers intend to breastfeed will be randomised to one of eight treatment conditions that include a combination of each of the three interventions: (i) intravenous amino acid solution vs. intravenous dextrose solution until full milk feeds established; (ii) milk supplement vs. exclusive breastmilk, and (iii) taste/smell given or not given before gastric tube feeds. Babies will be excluded if a particular mode of nutrition is clinically indicated or there is a congenital abnormality. Primary study outcome: For parenteral nutrition and milk supplement interventions, body composition at 4 months' corrected age. For taste/smell intervention, time to full enteral feeds defined as 150 ml.kg- 1.day- 1 or exclusive breastfeeding. Days to full sucking feeds; days in hospital; body composition at discharge; growth to 2 years' corrected age; development at 2 years' corrected age; breastfeeding rates. This trial will provide the first direct evidence to inform feeding practices in moderate- to late-preterm infants that will optimise their growth, metabolic and developmental outcomes. Australian New Zealand Clinical Trials Registry - ACTRN12616001199404 . This trial is endorsed by the IMPACT clinical trials network ( https://impact.psanz.com.au ). |
X Demographics
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| New Zealand | 1 | 25% |
| Italy | 1 | 25% |
| Unknown | 2 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 199 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 199 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 20 | 10% |
| Student > Master | 19 | 10% |
| Researcher | 15 | 8% |
| Student > Ph. D. Student | 13 | 7% |
| Student > Postgraduate | 11 | 6% |
| Other | 36 | 18% |
| Unknown | 85 | 43% |
| Readers by discipline | Count | As % |
|---|---|---|
| Nursing and Health Professions | 41 | 21% |
| Medicine and Dentistry | 37 | 19% |
| Biochemistry, Genetics and Molecular Biology | 6 | 3% |
| Psychology | 6 | 3% |
| Agricultural and Biological Sciences | 4 | 2% |
| Other | 18 | 9% |
| Unknown | 87 | 44% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 October 2022.
All research outputs
#13,269,866
of 23,485,296 outputs
Outputs from BMC Pediatrics
#1,598
of 3,116 outputs
Outputs of similar age
#159,121
of 328,670 outputs
Outputs of similar age from BMC Pediatrics
#64
of 82 outputs
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