| Title |
The effect of antidiabetic medications on non-alcoholic fatty liver disease (NAFLD)
|
|---|---|
| Published in |
Hormones international journal of endocrinology and metabolism, April 2018
|
| DOI | 10.1007/s42000-018-0021-9 |
| Pubmed ID | |
| Authors |
Laura Iogna Prat, Emmanuel A. Tsochatzis |
| Abstract |
Non-alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of the metabolic syndrome and is prevalent in more than 50% of patients with type II diabetes. At present, there is no approved therapy for NASH. Until now, the only proven effective interventions in improving biochemical and histological features of NASH, including fibrosis, are weight loss and physical activity even without weight loss. Because of the common epidemiological and pathophysiological features between NAFLD and T2DM, many antidiabetics drugs have been tested in patients with NAFLD over the years. Among these, pioglitazone and liraglutide seem to improve some histological features of NASH but have no clear effect on fibrosis. Metformin has been largely studied in the past years without convincing evidence of improving NAFLD. Data on other compounds such as DDP-4 and SGLT-2 inhibitors are limited. The rational and results of such studies are discussed in the present review. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 89 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 89 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 10 | 11% |
| Researcher | 9 | 10% |
| Student > Bachelor | 9 | 10% |
| Other | 8 | 9% |
| Student > Postgraduate | 7 | 8% |
| Other | 13 | 15% |
| Unknown | 33 | 37% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 35 | 39% |
| Biochemistry, Genetics and Molecular Biology | 8 | 9% |
| Nursing and Health Professions | 4 | 4% |
| Unspecified | 2 | 2% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 2% |
| Other | 4 | 4% |
| Unknown | 34 | 38% |
Attention Score in Context
This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 August 2022.
All research outputs
#3,623,572
of 25,382,440 outputs
Outputs from Hormones international journal of endocrinology and metabolism
#50
of 459 outputs
Outputs of similar age
#70,274
of 340,618 outputs
Outputs of similar age from Hormones international journal of endocrinology and metabolism
#6
of 25 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. Compared to these this one has done well and is in the 85th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 459 research outputs from this source. They receive a mean Attention Score of 4.9. This one has done well, scoring higher than 88% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 340,618 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 79% of its contemporaries.
We're also able to compare this research output to 25 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 76% of its contemporaries.