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X Demographics
Mendeley readers
Attention Score in Context
| Title |
The role of previously unmeasured organic acids in the pathogenesis of severe malaria
|
|---|---|
| Published in |
Critical Care, December 2015
|
| DOI | 10.1186/s13054-015-1023-5 |
| Pubmed ID | |
| Authors |
M. Trent Herdman, Natthida Sriboonvorakul, Stije J. Leopold, Sam Douthwaite, Sanjib Mohanty, M. Mahtab Uddin Hassan, Richard J. Maude, Hugh WF Kingston, Katherine Plewes, Prakaykaew Charunwatthana, Kamolrat Silamut, Charles J. Woodrow, Kesinee Chotinavich, Md. Amir Hossain, M. Abul Faiz, Saroj Mishra, Natchanun Leepipatpiboon, Nicholas J. White, Nicholas PJ Day, Joel Tarning, Arjen M. Dondorp |
| Abstract |
Severe falciparum malaria is commonly complicated by metabolic acidosis. Together with lactic acid (LA), other previously unmeasured acids have been implicated in the pathogenesis of falciparum malaria. In this prospective study, we characterised organic acids in adults with severe falciparum malaria in India and Bangladesh. Liquid chromatography-mass spectrometry was used to measure organic acids in plasma and urine. Patients were followed until recovery or death. Patients with severe malaria (n=138), uncomplicated malaria (n=102), sepsis (n=32) and febrile encephalopathy (n=35) were included. Strong ion gap (mean±SD) was elevated in severe malaria (8.2 mEq/L±4.5) and severe sepsis (8.6 mEq/L±7.7) compared with uncomplicated malaria (6.0 mEq/L±5.1) and encephalopathy (6.6 mEq/L±4.7). Compared with uncomplicated malaria, severe malaria was characterised by elevated plasma LA, hydroxyphenyllactic acid (HPLA), α-hydroxybutyric acid and β-hydroxybutyric acid (all P<0.05). In urine, concentrations of methylmalonic, ethylmalonic and α-ketoglutaric acids were also elevated. Multivariate logistic regression showed that plasma HPLA was a strong independent predictor of death (odds ratio [OR] 3.5, 95 % confidence interval [CI] 1.6-7.5, P=0.001), comparable to LA (OR 3.5, 95 % CI 1.5-7.8, P=0.003) (combined area under the receiver operating characteristic curve 0.81). Newly identified acids, in addition to LA, are elevated in patients with severe malaria and are highly predictive of fatal outcome. Further characterisation of their sources and metabolic pathways is now needed. |
X Demographics
The data shown below were collected from the profiles of 13 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 15% |
| Puerto Rico | 2 | 15% |
| Greece | 1 | 8% |
| United Kingdom | 1 | 8% |
| Thailand | 1 | 8% |
| Unknown | 6 | 46% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 6 | 46% |
| Practitioners (doctors, other healthcare professionals) | 4 | 31% |
| Science communicators (journalists, bloggers, editors) | 2 | 15% |
| Scientists | 1 | 8% |
Mendeley readers
The data shown below were compiled from readership statistics for 69 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 1 | 1% |
| Unknown | 68 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 11 | 16% |
| Student > Master | 10 | 14% |
| Student > Ph. D. Student | 7 | 10% |
| Student > Bachelor | 7 | 10% |
| Professor > Associate Professor | 5 | 7% |
| Other | 16 | 23% |
| Unknown | 13 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 36 | 52% |
| Biochemistry, Genetics and Molecular Biology | 6 | 9% |
| Immunology and Microbiology | 4 | 6% |
| Agricultural and Biological Sciences | 2 | 3% |
| Unspecified | 2 | 3% |
| Other | 6 | 9% |
| Unknown | 13 | 19% |
Attention Score in Context
This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 April 2016.
All research outputs
#5,187,758
of 25,371,288 outputs
Outputs from Critical Care
#3,375
of 6,554 outputs
Outputs of similar age
#79,667
of 395,397 outputs
Outputs of similar age from Critical Care
#282
of 466 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. Compared to these this one has done well and is in the 79th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 6,554 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 20.8. This one is in the 48th percentile – i.e., 48% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 395,397 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 79% of its contemporaries.
We're also able to compare this research output to 466 others from the same source and published within six weeks on either side of this one. This one is in the 39th percentile – i.e., 39% of its contemporaries scored the same or lower than it.