| Title |
Heart Rate Variability and Skin Conductance During Repetitive TMS Course in Children with Autism
|
|---|---|
| Published in |
Applied Psychophysiology and Biofeedback, September 2015
|
| DOI | 10.1007/s10484-015-9311-z |
| Pubmed ID | |
| Authors |
Yao Wang, Marie K. Hensley, Allan Tasman, Lonnie Sears, Manuel F. Casanova, Estate M. Sokhadze |
| Abstract |
Autism spectrum disorder (ASD) is a developmental disorder marked by difficulty in social interactions and communication. ASD also often present symptoms of autonomic nervous system (ANS) functioning abnormalities. In individuals with autism the sympathetic branch of the ANS presents an over-activation on a background of the parasympathetic activity deficits, creating an autonomic imbalance, evidenced by a faster heart rate with little variation and increased tonic electrodermal activity. The objective of this study was to explore the effect of 12 sessions of 0.5 Hz repetitive transcranial magnetic stimulation (rTMS) over dorsolateral prefrontal cortex (DLPFC) on autonomic activity in children with ASD. Electrocardiogram and skin conductance level (SCL) were recorded and analyzed during each session of rTMS. The measures of interest were time domain (i.e., R-R intervals, standard deviation of cardiac intervals, NN50-cardio-intervals >50 ms different from preceding interval) and frequency domain heart rate variability (HRV) indices [i.e., power of high frequency (HF) and low frequency (LF) components of HRV spectrum, LF/HF ratio]. Based on our prior pilot studies it was proposed that the course of 12 weekly inhibitory low-frequency rTMS bilaterally applied to the DLPFC will improve autonomic balance probably through improved frontal inhibition of the ANS activity, and will be manifested in an increased length of cardiointervals and their variability, and in higher frequency-domain HRV in a form of increased HF power, decreased LF power, resulting in decreased LF/HF ratio, and in decreased SCL. Our post-12 TMS results showed significant increases in cardiac intervals variability measures and decrease of tonic SCL indicative of increased cardiac vagal control and reduced sympathetic arousal. Behavioral evaluations showed decreased irritability, hyperactivity, stereotype behavior and compulsive behavior ratings that correlated with several autonomic variables. |
X Demographics
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 20% |
| Venezuela, Bolivarian Republic of | 1 | 20% |
| Spain | 1 | 20% |
| Canada | 1 | 20% |
| Unknown | 1 | 20% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 80% |
| Scientists | 1 | 20% |
Mendeley readers
The data shown below were compiled from readership statistics for 197 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Finland | 1 | <1% |
| United States | 1 | <1% |
| Unknown | 195 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 29 | 15% |
| Student > Ph. D. Student | 25 | 13% |
| Researcher | 21 | 11% |
| Student > Bachelor | 21 | 11% |
| Student > Doctoral Student | 17 | 9% |
| Other | 35 | 18% |
| Unknown | 49 | 25% |
| Readers by discipline | Count | As % |
|---|---|---|
| Psychology | 59 | 30% |
| Neuroscience | 22 | 11% |
| Medicine and Dentistry | 15 | 8% |
| Engineering | 12 | 6% |
| Sports and Recreations | 9 | 5% |
| Other | 26 | 13% |
| Unknown | 54 | 27% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 March 2016.
All research outputs
#14,452,294
of 25,654,806 outputs
Outputs from Applied Psychophysiology and Biofeedback
#268
of 461 outputs
Outputs of similar age
#124,589
of 278,210 outputs
Outputs of similar age from Applied Psychophysiology and Biofeedback
#8
of 11 outputs
Altmetric has tracked 25,654,806 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 461 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.6. This one is in the 41st percentile – i.e., 41% of its peers scored the same or lower than it.
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We're also able to compare this research output to 11 others from the same source and published within six weeks on either side of this one. This one is in the 27th percentile – i.e., 27% of its contemporaries scored the same or lower than it.