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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Sequence-specific activation of the DNA sensor cGAS by Y-form DNA structures as found in primary HIV-1 cDNA
|
|---|---|
| Published in |
Nature Immunology, September 2015
|
| DOI | 10.1038/ni.3267 |
| Pubmed ID | |
| Authors |
Anna-Maria Herzner, Cristina Amparo Hagmann, Marion Goldeck, Steven Wolter, Kirsten Kübler, Sabine Wittmann, Thomas Gramberg, Liudmila Andreeva, Karl-Peter Hopfner, Christina Mertens, Thomas Zillinger, Tengchuan Jin, Tsan Sam Xiao, Eva Bartok, Christoph Coch, Damian Ackermann, Veit Hornung, Janos Ludwig, Winfried Barchet, Gunther Hartmann, Martin Schlee |
| Abstract |
Cytosolic DNA that emerges during infection with a retrovirus or DNA virus triggers antiviral type I interferon responses. So far, only double-stranded DNA (dsDNA) over 40 base pairs (bp) in length has been considered immunostimulatory. Here we found that unpaired DNA nucleotides flanking short base-paired DNA stretches, as in stem-loop structures of single-stranded DNA (ssDNA) derived from human immunodeficiency virus type 1 (HIV-1), activated the type I interferon-inducing DNA sensor cGAS in a sequence-dependent manner. DNA structures containing unpaired guanosines flanking short (12- to 20-bp) dsDNA (Y-form DNA) were highly stimulatory and specifically enhanced the enzymatic activity of cGAS. Furthermore, we found that primary HIV-1 reverse transcripts represented the predominant viral cytosolic DNA species during early infection of macrophages and that these ssDNAs were highly immunostimulatory. Collectively, our study identifies unpaired guanosines in Y-form DNA as a highly active, minimal cGAS recognition motif that enables detection of HIV-1 ssDNA. |
X Demographics
The data shown below were collected from the profiles of 10 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | 20% |
| Malaysia | 1 | 10% |
| United States | 1 | 10% |
| Unknown | 6 | 60% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 7 | 70% |
| Science communicators (journalists, bloggers, editors) | 3 | 30% |
Mendeley readers
The data shown below were compiled from readership statistics for 265 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Poland | 1 | <1% |
| France | 1 | <1% |
| Unknown | 263 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 69 | 26% |
| Researcher | 53 | 20% |
| Student > Bachelor | 30 | 11% |
| Student > Master | 25 | 9% |
| Other | 14 | 5% |
| Other | 35 | 13% |
| Unknown | 39 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 71 | 27% |
| Agricultural and Biological Sciences | 59 | 22% |
| Immunology and Microbiology | 46 | 17% |
| Medicine and Dentistry | 12 | 5% |
| Chemistry | 10 | 4% |
| Other | 22 | 8% |
| Unknown | 45 | 17% |
Attention Score in Context
This research output has an Altmetric Attention Score of 98. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 September 2023.
All research outputs
#441,169
of 25,866,425 outputs
Outputs from Nature Immunology
#309
of 4,251 outputs
Outputs of similar age
#5,553
of 279,943 outputs
Outputs of similar age from Nature Immunology
#2
of 49 outputs
Altmetric has tracked 25,866,425 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,251 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 35.4. This one has done particularly well, scoring higher than 92% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 279,943 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 49 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 95% of its contemporaries.