| Title |
Modelling the Epidemiological Impact and Cost-Effectiveness of PrEP for HIV Transmission in MSM in China
|
|---|---|
| Published in |
AIDS and Behavior, July 2018
|
| DOI | 10.1007/s10461-018-2205-3 |
| Pubmed ID | |
| Authors |
Lei Zhang, Peng Peng, Yumeng Wu, Xiaomeng Ma, Nyi Nyi Soe, Xiaojie Huang, Hao Wu, Martin Markowitz, Kathrine Meyers |
| Abstract |
Risk of HIV infection is high in Chinese MSM, with an annual HIV incidence ranging from 3.41 to 13.7/100 person-years. Tenofovir-based PrEP is effective in preventing HIV transmission in MSM. This study evaluates the epidemiological impact and cost-effectiveness of implementing PrEP in Chinese MSM over the next two decades. A compartmental model for HIV was used to forecast the impact of PrEP on number of infections, deaths, and disability-adjusted life years (DALY) averted. We also provide an estimate of the incremental cost-effectiveness ratio (ICER) and the cost per DALY averted of the intervention. Without PrEP, there will be 1.1-3.0 million new infections and 0.7-2.3 million HIV-related deaths in the next two decades. Moderate PrEP coverage (50%) would prevent 0.17-0.32 million new HIV infections. At Truvada's current price in China, daily oral PrEP costs $46,813-52,008 per DALY averted and is not cost-effective; on-demand Truvada reduces ICER to $25,057-27,838 per DALY averted, marginally cost-effective; daily generic tenofovir-based regimens further reduce ICER to $3675-8963, wholly cost-effective. The cost of daily oral Truvada PrEP regimen would need to be reduced by half to achieve cost-effectiveness and realize the public health good of preventing hundreds of thousands of HIV infections among MSM in China. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 97 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 97 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 18 | 19% |
| Researcher | 13 | 13% |
| Student > Ph. D. Student | 7 | 7% |
| Student > Doctoral Student | 5 | 5% |
| Student > Postgraduate | 5 | 5% |
| Other | 15 | 15% |
| Unknown | 34 | 35% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 16 | 16% |
| Nursing and Health Professions | 13 | 13% |
| Social Sciences | 6 | 6% |
| Psychology | 4 | 4% |
| Engineering | 3 | 3% |
| Other | 16 | 16% |
| Unknown | 39 | 40% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 December 2020.
All research outputs
#7,612,318
of 23,849,058 outputs
Outputs from AIDS and Behavior
#1,310
of 3,566 outputs
Outputs of similar age
#126,883
of 329,728 outputs
Outputs of similar age from AIDS and Behavior
#30
of 90 outputs
Altmetric has tracked 23,849,058 research outputs across all sources so far. This one has received more attention than most of these and is in the 67th percentile.
So far Altmetric has tracked 3,566 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.0. This one has gotten more attention than average, scoring higher than 62% of its peers.
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We're also able to compare this research output to 90 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 65% of its contemporaries.