| Title |
Ab-normal saline in abnormal kidney function: risks and alternatives
|
|---|---|
| Published in |
Pediatric Nephrology, July 2018
|
| DOI | 10.1007/s00467-018-4008-1 |
| Pubmed ID | |
| Authors |
Wesley Hayes |
| Abstract |
Intravenous 0.9% saline has saved countless lives since it was introduced over a century ago. It remains the most widespread crystalloid in both adult and pediatric practice. However, in recent years, evidence of deleterious effects is accruing. These include increased mortality, acute kidney injury (AKI), metabolic acidosis, and coagulopathy. The predominant cause for these sequelae appears to be the excess chloride concentration of 0.9% saline relative to plasma. This has led to development of balanced isotonic solutions such as PlasmaLyte. This review summarizes current evidence for adverse effects of chloride-rich intravenous fluid and considers whether 0.9% saline should still be used in 2018 or abandoned as a historical treatment in favor of balanced crystalloid solutions. |
X Demographics
The data shown below were collected from the profiles of 26 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 4 | 15% |
| United States | 4 | 15% |
| Canada | 2 | 8% |
| Argentina | 2 | 8% |
| Mexico | 1 | 4% |
| Colombia | 1 | 4% |
| Philippines | 1 | 4% |
| Australia | 1 | 4% |
| Unknown | 10 | 38% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 17 | 65% |
| Practitioners (doctors, other healthcare professionals) | 5 | 19% |
| Scientists | 2 | 8% |
| Science communicators (journalists, bloggers, editors) | 2 | 8% |
Mendeley readers
The data shown below were compiled from readership statistics for 46 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 46 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 8 | 17% |
| Other | 5 | 11% |
| Professor > Associate Professor | 3 | 7% |
| Student > Master | 3 | 7% |
| Student > Doctoral Student | 2 | 4% |
| Other | 5 | 11% |
| Unknown | 20 | 43% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 16 | 35% |
| Nursing and Health Professions | 3 | 7% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 4% |
| Veterinary Science and Veterinary Medicine | 2 | 4% |
| Business, Management and Accounting | 1 | 2% |
| Other | 4 | 9% |
| Unknown | 18 | 39% |
Attention Score in Context
This research output has an Altmetric Attention Score of 18. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 June 2023.
All research outputs
#2,043,596
of 25,051,161 outputs
Outputs from Pediatric Nephrology
#162
of 3,998 outputs
Outputs of similar age
#41,003
of 332,424 outputs
Outputs of similar age from Pediatric Nephrology
#3
of 81 outputs
Altmetric has tracked 25,051,161 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 91st percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,998 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.2. This one has done particularly well, scoring higher than 95% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 332,424 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 87% of its contemporaries.
We're also able to compare this research output to 81 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 97% of its contemporaries.