Title |
The effect of administration of fenbendazole on the microbial hindgut population of the horse
|
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Published in |
Journal of Equine Science, July 2018
|
DOI | 10.1294/jes.29.47 |
Pubmed ID | |
Authors |
Laura CROTCH-HARVEY, Leigh-Anne THOMAS, Hilary J. WORGAN, Jamie-Leigh DOUGLAS, Diane E. GILBY, Neil R. MCEWAN |
Abstract |
Anthelmintics are used as anti-worming agents. Although known to affect their target organisms, nothing has been published regarding their effect on other digestive tract organisms or on metabolites produced by them. The current work investigated effects of fenbendazole, a benzimidazole anthelmintic, on bacteria and ciliates in the equine digestive tract and on and their major metabolites. Animals receiving anthelmintic treatment had high faecal egg counts relative to controls. Analysis was performed over two weeks, with temporal differences detected in bacterial populations but with no other significant differences detected. This suggests fenbendazole has no detectable effect on organisms other than its targets. Moreover it does not appear to make a contribution to changing the resulting metabolome. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 13 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 5 | 38% |
Student > Ph. D. Student | 3 | 23% |
Student > Postgraduate | 2 | 15% |
Student > Bachelor | 1 | 8% |
Unknown | 2 | 15% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 6 | 46% |
Veterinary Science and Veterinary Medicine | 3 | 23% |
Biochemistry, Genetics and Molecular Biology | 1 | 8% |
Chemistry | 1 | 8% |
Unknown | 2 | 15% |