Title |
Topical henna for capecitabine induced hand–foot syndrome
|
---|---|
Published in |
Investigational New Drugs, September 2007
|
DOI | 10.1007/s10637-007-9082-3 |
Pubmed ID | |
Authors |
Idris Yucel, Gonullu Guzin |
Abstract |
Capecitabine is a chemotherapeutic drug for use in cancers. Hand-foot syndrome (HFS) is side effect of capecitabine which can lead the cessation of the therapy or dose reduction. Henna (Lawsonia inermis) is a traditionally used plant of Middle-East that is applied on hands and feet. Some of cancer patients in capecitabine treatment who developed HFS, we recommended to apply henna. In these patients, six patients were grade 3 HFS and four were grade 2 HFS. Complete response (CR) were seen in four of grade 3 HFS and all of grade 2; two grade 3 HFS improved to grade 1. So far, in the chemotherapy, there was no need of dose reduction and also no side effect of henna seen. Clinical improvement in these patients may relate to anti-inflammatory, antipyretic and analgesic effects of henna. Prospective studies are needed to show this therapeutic effect of henna. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
India | 1 | 25% |
United States | 1 | 25% |
Unknown | 2 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 3 | 75% |
Science communicators (journalists, bloggers, editors) | 1 | 25% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 28 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 6 | 21% |
Student > Postgraduate | 3 | 11% |
Professor > Associate Professor | 3 | 11% |
Student > Master | 3 | 11% |
Researcher | 2 | 7% |
Other | 7 | 25% |
Unknown | 4 | 14% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 9 | 32% |
Biochemistry, Genetics and Molecular Biology | 4 | 14% |
Agricultural and Biological Sciences | 3 | 11% |
Nursing and Health Professions | 2 | 7% |
Unspecified | 1 | 4% |
Other | 3 | 11% |
Unknown | 6 | 21% |