| Title |
Accelerated partial breast irradiation using intensity-modulated radiotherapy technique compared to whole breast irradiation for patients aged 70 years or older: subgroup analysis from a randomized phase 3 trial
|
|---|---|
| Published in |
Breast Cancer Research and Treatment, September 2015
|
| DOI | 10.1007/s10549-015-3565-2 |
| Pubmed ID | |
| Authors |
Icro Meattini, Calogero Saieva, Livia Marrazzo, Lucia Di Brina, Stefania Pallotta, Monica Mangoni, Fiammetta Meacci, Benedetta Bendinelli, Giulio Francolini, Isacco Desideri, Carla De Luca Cardillo, Vieri Scotti, Ilaria Francesca Furfaro, Francesca Rossi, Daniela Greto, Pierluigi Bonomo, Donato Casella, Marco Bernini, Luis Sanchez, Lorenzo Orzalesi, Roberta Simoncini, Jacopo Nori, Simonetta Bianchi, Lorenzo Livi |
| Abstract |
The purpose of this study was to report the efficacy and the safety profile on the subset of selected early breast cancer (BC) patients aged 70 years or older from a single-center phase 3 trial comparing whole breast irradiation (WBI) to accelerated partial breast irradiation (APBI) using intensity-modulated radiation therapy technique. Between 2005 and 2013, 520 patients aged more than 40 years old were enrolled and randomly assigned to receive either WBI or APBI in a 1:1 ratio. Eligible patients were women with early BC (maximum diameter 2.5 cm) suitable for breast conserving surgery. This study is registered with ClinicalTrials.gov, NCT02104895. A total of 117 patients aged 70 years or more were analyzed (58 in the WBI arm, 59 in the APBI arm). At a median follow-up of 5-years (range 3.4-7.0), the ipsilateral breast tumor recurrence (IBTR) rate was 1.9 % in both groups. No significant difference between the two groups was identified (log-rank test p = 0.96). The 5-year disease-free survival (DFS) rates in the WBI group and APBI group were 6.1 and 1.9 %, respectively (p = 0.33). The APBI group presented significantly better results in terms of acute skin toxicity, considering both any grade (p = 0.0001) and grade 2 or higher (p = 0.0001). Our subgroup analyses showed a very low rate and no significant difference in terms of IBTR, using both WBI and APBI. A significant impact on patients compliance in terms of acute and early late toxicity was shown, which could translate in a consistent improvement of overall quality of life. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 87 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 87 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 15 | 17% |
| Student > Master | 11 | 13% |
| Student > Bachelor | 8 | 9% |
| Other | 7 | 8% |
| Student > Postgraduate | 5 | 6% |
| Other | 15 | 17% |
| Unknown | 26 | 30% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 34 | 39% |
| Nursing and Health Professions | 7 | 8% |
| Physics and Astronomy | 4 | 5% |
| Psychology | 3 | 3% |
| Biochemistry, Genetics and Molecular Biology | 2 | 2% |
| Other | 8 | 9% |
| Unknown | 29 | 33% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 July 2018.
All research outputs
#7,222,086
of 22,828,180 outputs
Outputs from Breast Cancer Research and Treatment
#1,584
of 4,659 outputs
Outputs of similar age
#86,323
of 267,220 outputs
Outputs of similar age from Breast Cancer Research and Treatment
#21
of 87 outputs
Altmetric has tracked 22,828,180 research outputs across all sources so far. This one has received more attention than most of these and is in the 67th percentile.
So far Altmetric has tracked 4,659 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.2. This one has gotten more attention than average, scoring higher than 64% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 267,220 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 66% of its contemporaries.
We're also able to compare this research output to 87 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 74% of its contemporaries.