Recently, three molecular subgroups of atypical teratoid/rhabdoid tumor (ATRT) were identified, but little is known on their clinical and magnetic resonance imaging (MRI) characteristics.
A total of 43 patients with known molecular subgroup status (ATRT-SHH n=17, ATRT-TYR n=16, ATRT-MYC n=10) were retrieved from the EU-RHAB registry and analyzed for clinical and MRI features.
On MRI review, differences in preferential tumor location were confirmed, with ATRT-TYR being predominantly located infratentorially (p<.05). Peritumoral edema was more pronounced in ATRT-MYC, compared to ATRT-SHH (p<.05) and ATRT-TYR (p<.05). Conversely, peripheral tumor cysts were found more frequently in ATRT-SHH (71%) and ATRT-TYR (94%), as compared to ATRT-MYC (40%, p<.05). Contrast enhancement was absent in 29% of ATRT-SHH (0% of ATRT-TYR; 10% of ATRT-MYC; p<.05), and there was a trend towards strong contrast enhancement in ATRT-TYR and ATRT-MYC. We found the characteristic (band-like) enhancement in 28% of ATRT as well as restricted diffusion in the majority of tumors. A midline/off-midline location in the posterior fossa was also not subgroup-specific. Visible meningeal spread (M2) at diagnosis was rare throughout all subgroups.
These exploratory findings suggest that MRI features vary across the three molecular subgroups of ATRT. Within future prospective trials, MRI may aid diagnosis and treatment stratification.
Pharmacology, Toxicology and Pharmaceutical Science
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Attention Score in Context
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 September 2018.
All research outputs
#17,982,872
of 23,096,849 outputs
Outputs from Neuro-Oncology
#2,281
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Outputs of similar age
#236,171
of 327,048 outputs
Outputs of similar age from Neuro-Oncology
#30
of 87 outputs
Altmetric has tracked 23,096,849 research outputs across all sources so far. This one is in the 19th percentile – i.e., 19% of other outputs scored the same or lower than it.
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