| Title |
Post-radiosurgical edema associated with parasagittal and parafalcine meningiomas: a multicenter study
|
|---|---|
| Published in |
Journal of Neuro-Oncology, September 2015
|
| DOI | 10.1007/s11060-015-1911-1 |
| Pubmed ID | |
| Authors |
Jason P. Sheehan, Or Cohen-Inbar, Rawee Ruangkanchanasetr, S. Bulent Omay, Judith Hess, Veronica Chiang, Christian Iorio-Morin, Michelle Alonso-Basanta, David Mathieu, Inga S. Grills, John Y. K. Lee, Cheng-Chia Lee, L. Dade Lunsford |
| Abstract |
Stereotactic radiosurgery (SRS) offers a high degree of tumor control for benign meningiomas. However, radiosurgery can occasionally incite edema or exacerbate pre-existing peri-tumoral edema. The current study investigates the incidence, timing, and extent of edema around parasagittal or parafalcine meningiomas following SRS. A retrospective multicenter review was undertaken through participating centers in the International Gamma Knife Research Foundation (previously the North American Gamma Knife Consortium or NAGKC). All included patients had a parafalcine or parasagittal meningioma and a minimum of 6 months follow up. The median follow up was 19.6 months (6-158 months). Extent of new or worsening edema was quantitatively analyzed using volumetric analysis; edema indices were longitudinally computed following radiosurgery. Analysis was performed to identify prognostic factors for new or worsening edema. A cohort of 212 patients comprised of 51.9 % (n = 110) females, 40.1 % upfront SRS and 59.9 % underwent adjuvant SRS for post-surgical residual tumor. The median tumor volume at SRS was 5.2 ml. Venous sinus compression or invasion was demonstrated in 25 % (n = 53). The median marginal dose was 14 Gy (8-20 Gy). Tumor volume control was determined in 77.4 % (n = 164 out of 212 patients). Tumor edema progressed and then regressed in 33 % (n = 70), was stable or regressed in 52.8 % (n = 112), and progressively worsened in 5.2 % (n = 11). Tumor location, tumor volume, venous sinus invasion, margin, and maximal dose were found to be significantly related to post-SRS edema in multivariate analysis. SRS affords a high degree of tumor control for patients with parasagittal or parafalcine meningiomas. Nevertheless, SRS can lead to worsening peritumoral edema in a subset of patients such as those with larger tumors (>10 cc) and venous sinus invasion/compression. Long-term follow up is required to detect and appropriately manage post-SRS edema. |
Mendeley readers
The data shown below were compiled from readership statistics for 48 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Belgium | 1 | 2% |
| Unknown | 47 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 12 | 25% |
| Other | 6 | 13% |
| Student > Postgraduate | 6 | 13% |
| Student > Bachelor | 4 | 8% |
| Unspecified | 3 | 6% |
| Other | 11 | 23% |
| Unknown | 6 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 24 | 50% |
| Neuroscience | 6 | 13% |
| Unspecified | 3 | 6% |
| Agricultural and Biological Sciences | 2 | 4% |
| Biochemistry, Genetics and Molecular Biology | 1 | 2% |
| Other | 1 | 2% |
| Unknown | 11 | 23% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 July 2018.
All research outputs
#7,573,552
of 23,096,849 outputs
Outputs from Journal of Neuro-Oncology
#1,066
of 2,992 outputs
Outputs of similar age
#90,760
of 267,684 outputs
Outputs of similar age from Journal of Neuro-Oncology
#7
of 68 outputs
Altmetric has tracked 23,096,849 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,992 research outputs from this source. They receive a mean Attention Score of 4.2. This one is in the 48th percentile – i.e., 48% of its peers scored the same or lower than it.
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We're also able to compare this research output to 68 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 88% of its contemporaries.