Title |
NF-κB signaling in cancer stem cells: a promising therapeutic target?
|
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Published in |
Cellular Oncology, August 2015
|
DOI | 10.1007/s13402-015-0236-6 |
Pubmed ID | |
Authors |
K. Vazquez-Santillan, J. Melendez-Zajgla, L. Jimenez-Hernandez, G. Martínez-Ruiz, V. Maldonado |
Abstract |
Cancer stem cells (CSCs) are regulated by several signaling pathways that ultimately control their maintenance and expansion. NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) forms a protein complex that controls DNA transcription and, as such, plays an important role in proliferation, inflammation, angiogenesis, invasion and metastasis. The NF-κB signaling pathway, which has been found to be constitutively activated in CSCs from a variety of cancers, participates in the maintenance, expansion, proliferation and survival of CSCs. Targeted disruption of this pathway may profoundly impair the adverse phenotype of CSCs and may provide a therapeutic opportunity to remove the CSC fraction. In particular, it may be attractive to use specific NF-κB inhibitors in chronic therapeutic schemes to reduce disease progression. Exceptional low toxicity profiles of these inhibitors are a prerequisite for use in combined treatment regimens and to avoid resistance. Although still preliminary, recent evidence shows that such targeted strategies may be useful in adjuvant chemo-preventive settings. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 50% |
Science communicators (journalists, bloggers, editors) | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 70 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 13 | 19% |
Student > Bachelor | 11 | 16% |
Student > Ph. D. Student | 10 | 14% |
Student > Master | 7 | 10% |
Student > Doctoral Student | 5 | 7% |
Other | 6 | 9% |
Unknown | 18 | 26% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 22 | 31% |
Medicine and Dentistry | 12 | 17% |
Agricultural and Biological Sciences | 7 | 10% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 4% |
Nursing and Health Professions | 2 | 3% |
Other | 5 | 7% |
Unknown | 19 | 27% |