| Title |
Muscle health and performance in monozygotic twins with 30 years of discordant exercise habits
|
|---|---|
| Published in |
European Journal of Applied Physiology, July 2018
|
| DOI | 10.1007/s00421-018-3943-7 |
| Pubmed ID | |
| Authors |
Katherine E. Bathgate, James R. Bagley, Edward Jo, Robert J. Talmadge, Irene S. Tobias, Lee E. Brown, Jared W. Coburn, Jose A. Arevalo, Nancy L. Segal, Andrew J. Galpin |
| Abstract |
Physical health and function depend upon both genetic inheritance and environmental factors (e.g., exercise training). To enhance the understanding of heritability/adaptability, we explored the skeletal muscle health and physiological performance of monozygotic (MZ) twins with > 30 years of chronic endurance training vs. no specific/consistent exercise. One pair of male MZ twins (age = 52 years; Trained Twin, TT; Untrained Twin, UT) underwent analyses of: (1) anthropometric characteristics and blood profiles, (2) markers of cardiovascular and pulmonary health, and (3) skeletal muscle size, strength, and power and molecular markers of muscle health. This case study represents the most comprehensive physiological comparison of MZ twins with this length and magnitude of differing exercise history. TT exhibited: (1) lower body mass, body fat%, resting heart rate, blood pressure, cholesterol, triglycerides, and plasma glucose, (2) greater relative cycling power, anaerobic endurance, and aerobic capacity (VO2max), but lower muscle size/strength and poorer muscle quality, (3) more MHC I (slow-twitch) and fewer MHC IIa (fast-twitch) fibers, (4) greater AMPK protein expression, and (5) greater PAX7, IGF1Ec, IGF1Ea, and FN14 mRNA expression than UT. Several measured differences are the largest reported between MZ twins (TT expressed 55% more MHC I fibers, 12.4 ml/kg/min greater VO2max, and 8.6% lower body fat% vs. UT). These data collectively (a) support utilizing chronic endurance training to improve body composition and cardiovascular health and (b) suggest the cardiovascular and skeletal muscle systems exhibit greater plasticity than previously thought, further highlighting the importance of studying MZ twins with large (long-term) differences in exposomes. |
X Demographics
The data shown below were collected from the profiles of 365 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 78 | 21% |
| United Kingdom | 35 | 10% |
| Canada | 31 | 8% |
| Spain | 24 | 7% |
| Australia | 10 | 3% |
| Germany | 6 | 2% |
| Brazil | 6 | 2% |
| Ireland | 5 | 1% |
| Sweden | 5 | 1% |
| Other | 38 | 10% |
| Unknown | 127 | 35% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 229 | 63% |
| Scientists | 93 | 25% |
| Practitioners (doctors, other healthcare professionals) | 41 | 11% |
| Science communicators (journalists, bloggers, editors) | 2 | <1% |
Mendeley readers
The data shown below were compiled from readership statistics for 167 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 167 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 25 | 15% |
| Student > Master | 23 | 14% |
| Student > Ph. D. Student | 19 | 11% |
| Researcher | 11 | 7% |
| Student > Doctoral Student | 10 | 6% |
| Other | 26 | 16% |
| Unknown | 53 | 32% |
| Readers by discipline | Count | As % |
|---|---|---|
| Sports and Recreations | 48 | 29% |
| Biochemistry, Genetics and Molecular Biology | 17 | 10% |
| Medicine and Dentistry | 9 | 5% |
| Nursing and Health Professions | 6 | 4% |
| Agricultural and Biological Sciences | 5 | 3% |
| Other | 25 | 15% |
| Unknown | 57 | 34% |
Attention Score in Context
This research output has an Altmetric Attention Score of 305. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 November 2023.
All research outputs
#115,303
of 25,793,330 outputs
Outputs from European Journal of Applied Physiology
#23
of 4,395 outputs
Outputs of similar age
#2,393
of 341,301 outputs
Outputs of similar age from European Journal of Applied Physiology
#1
of 61 outputs
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