Title |
Wnt signaling pathways in myocardial infarction and the therapeutic effects of Wnt pathway inhibitors
|
---|---|
Published in |
Acta Pharmacologica Sinica, July 2018
|
DOI | 10.1038/s41401-018-0060-4 |
Pubmed ID | |
Authors |
Wen-bin Fu, Wei Eric Wang, Chun-yu Zeng |
Abstract |
Myocardial infarction (MI) is one of the most serious health threats, resulting in huge physical and economic burdens worldwide. Wnt signaling pathways play an important role in developmental processes such as tissue patterning, cell differentiation and cell division. Appropriate regulation of the activities of Wnt signaling pathways is also important for heart development and healing in post-MI heart. Moreover, Wnt pathway inhibitors have been identified as novel antitumor drugs and applied in ongoing clinical trials. This research progress has generated increasing interests for investigating the effects of Wnt pathway inhibitors on MI healing. In this short review, we summarize the roles of Wnt signaling pathways in post-MI heart and the therapeutic effects of Wnt pathway inhibitors on MI, and discuss the underlying mechanisms of Wnt pathway inhibitors in cardiac repairing. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 71 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 13 | 18% |
Student > Ph. D. Student | 12 | 17% |
Student > Bachelor | 9 | 13% |
Student > Postgraduate | 4 | 6% |
Student > Doctoral Student | 2 | 3% |
Other | 3 | 4% |
Unknown | 28 | 39% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 23 | 32% |
Medicine and Dentistry | 8 | 11% |
Agricultural and Biological Sciences | 4 | 6% |
Chemistry | 2 | 3% |
Economics, Econometrics and Finance | 2 | 3% |
Other | 4 | 6% |
Unknown | 28 | 39% |