| Title |
Environmental Susceptibility of the Sperm Epigenome During Windows of Male Germ Cell Development
|
|---|---|
| Published in |
Current Environmental Health Reports, September 2015
|
| DOI | 10.1007/s40572-015-0067-7 |
| Pubmed ID | |
| Authors |
Haotian Wu, Russ Hauser, Stephen A. Krawetz, J. Richard Pilsner |
| Abstract |
Male germ cells require multiple epigenetic reprogramming events during their lifespan to achieve reproductive capacity. An emerging body of compelling data demonstrates that environmental exposures can be embodied within the developing male germ cell as epigenetic marks. In turn, these epigenetic marks can impart information at fertilization to affect the trajectory of offspring health and development. While it is recognized that in utero epigenetic reprogramming of male germ cells is a particularly susceptible window to environmental exposures, other such windows exist during germ cell development. The objective of this review is to discuss epigenetic reprogramming events during male germ cell development and to provide supporting evidence from animal and human studies that during specific periods of development, germ cells are susceptible to environmentally induced epigenetic errors. Moving forward, the nascent field of sperm epigenetics research is likely to advance our understanding of paternal environmental determinants of offspring health and development. |
X Demographics
The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 40% |
| Unknown | 3 | 60% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 5 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 108 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Argentina | 1 | <1% |
| Unknown | 107 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 22 | 20% |
| Researcher | 15 | 14% |
| Student > Bachelor | 14 | 13% |
| Student > Master | 11 | 10% |
| Other | 7 | 6% |
| Other | 16 | 15% |
| Unknown | 23 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 27 | 25% |
| Agricultural and Biological Sciences | 20 | 19% |
| Medicine and Dentistry | 10 | 9% |
| Pharmacology, Toxicology and Pharmaceutical Science | 4 | 4% |
| Environmental Science | 3 | 3% |
| Other | 14 | 13% |
| Unknown | 30 | 28% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 June 2016.
All research outputs
#13,213,964
of 22,828,180 outputs
Outputs from Current Environmental Health Reports
#226
of 324 outputs
Outputs of similar age
#122,564
of 267,781 outputs
Outputs of similar age from Current Environmental Health Reports
#10
of 11 outputs
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