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Genes influence the amplitude and timing of brain hemodynamic responses

Overview of attention for article published in NeuroImage, September 2015
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (86th percentile)
  • Good Attention Score compared to outputs of the same age and source (79th percentile)

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23 X users

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Title
Genes influence the amplitude and timing of brain hemodynamic responses
Published in
NeuroImage, September 2015
DOI 10.1016/j.neuroimage.2015.09.016
Pubmed ID
Authors

Zuyao Y. Shan, Anna A.E. Vinkhuyzen, Paul M. Thompson, Katie L. McMahon, Gabriëlla A.M. Blokland, Greig I. de Zubicaray, Vince Calhoun, Nicholas G. Martin, Peter M. Visscher, Margaret J. Wright, David C. Reutens

Abstract

In functional magnetic resonance imaging (fMRI), the hemodynamic response function (HRF) reflects regulation of regional cerebral blood flow in response to neuronal activation. The HRF varies significantly between individuals. This study investigated the genetic contribution to individual variation in HRF using fMRI data from 125 monozygotic (MZ) and 149 dizygotic (DZ) twin pairs. The resemblance in amplitude, latency, and duration of the HRF in six regions in the frontal and parietal lobes was compared between MZ and DZ twin pairs. Heritability was estimated using an ACE (Additive genetic, Common environmental, and unique Environmental factors) model. The genetic influence on the temporal profile and amplitude of HRF was moderate to strong (24%-51%). The HRF may be used in the genetic analysis of diseases with a cerebrovascular etiology.

X Demographics

X Demographics

The data shown below were collected from the profiles of 23 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 66 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Switzerland 2 3%
Germany 1 2%
Netherlands 1 2%
Belgium 1 2%
United States 1 2%
Unknown 60 91%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 15 23%
Researcher 13 20%
Student > Bachelor 5 8%
Student > Doctoral Student 4 6%
Other 4 6%
Other 13 20%
Unknown 12 18%
Readers by discipline Count As %
Neuroscience 13 20%
Psychology 8 12%
Agricultural and Biological Sciences 7 11%
Engineering 6 9%
Medicine and Dentistry 5 8%
Other 8 12%
Unknown 19 29%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 13. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 September 2016.
All research outputs
#2,861,804
of 25,738,558 outputs
Outputs from NeuroImage
#2,355
of 12,284 outputs
Outputs of similar age
#36,707
of 281,244 outputs
Outputs of similar age from NeuroImage
#47
of 233 outputs
Altmetric has tracked 25,738,558 research outputs across all sources so far. Compared to these this one has done well and is in the 88th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 12,284 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.6. This one has done well, scoring higher than 80% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 281,244 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 86% of its contemporaries.
We're also able to compare this research output to 233 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 79% of its contemporaries.