Title |
Cardiovascular Risk Assessment in Patients with Hypertriglyceridemia
|
---|---|
Published in |
Current Cardiology Reports, July 2018
|
DOI | 10.1007/s11886-018-1013-8 |
Pubmed ID | |
Authors |
Matthew C. Evans, Tapati Stalam, Michael Miller |
Abstract |
Assessing the cardiovascular risk associated with hypertriglyceridemia can be challenging due to frequent confounding conditions such as hypertension, diabetes mellitus, and hyperlipidemia. We sought to quantify this risk by examining several meta-analyses as well as subgroup analyses of previously published major randomized controlled trials that focused on the treatment of hyperlipidemia. Recent trials measuring the effects of PCSK9 inhibitors such as evolocumab and alirocumab on cardiovascular outcomes have demonstrated a high degree of residual cardiovascular risk even after profound reductions in low-density-lipoprotein cholesterol (LDL-C). Despite optimization of LDL-C through the use of statins, PCSK9 inhibitors and adjunctive therapies such as ezetimibe, bile acid sequestrants and niacin, residual cardiovascular risk remains significant. Several ongoing trials are assessing the efficacy of pemafibrate and omega-3 fatty acids for the treatment of hypertriglyceridemia and their effects on major cardiovascular outcomes. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 5 | 63% |
Germany | 1 | 13% |
Unknown | 2 | 25% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 5 | 63% |
Scientists | 2 | 25% |
Practitioners (doctors, other healthcare professionals) | 1 | 13% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 32 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Bachelor | 5 | 16% |
Student > Master | 4 | 13% |
Student > Doctoral Student | 3 | 9% |
Student > Ph. D. Student | 3 | 9% |
Librarian | 2 | 6% |
Other | 6 | 19% |
Unknown | 9 | 28% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 11 | 34% |
Pharmacology, Toxicology and Pharmaceutical Science | 4 | 13% |
Nursing and Health Professions | 4 | 13% |
Biochemistry, Genetics and Molecular Biology | 1 | 3% |
Unknown | 12 | 38% |