| Title |
Nizwaside: a new anticancer pregnane glycoside from the sap of Desmidorchis flava
|
|---|---|
| Published in |
Archives of Pharmacal Research, September 2015
|
| DOI | 10.1007/s12272-015-0653-0 |
| Pubmed ID | |
| Authors |
Hidayat Hussain, Muhammad Adil Raees, Najeeb Ur Rehman, Ahmed Al-Rawahi, René Csuk, Husain Yar Khan, Ghulam Abbas, Mohammed Abdullah Al-Broumi, Ivan R. Green, Ali Elyassi, Talat Mahmood, Ahmed Al-Harrasi |
| Abstract |
The sap from the succulent Desmidorchis flava (N.E.Br) Meve and Liede yielded a new pregnane glycoside, named nizwaside whose structure was established using 1D and 2D NMR techniques as well as mass spectrometry (ESIMS). Nizwaside was tested for anticancer, DPPH antioxidant, urease enzyme inhibition, α-glucosidase enzyme inhibition and acetylcholinesterase inhibition activities. Interestingly, nizwaside showed significant anti-proliferative effects on MDA MB231 breast cancer cells with an IC50 of 23.5 µg/ml. Moreover, nizwaside was more effective than Doxorubicin, a well-known clinical anticancer drug, in suppressing MDA MB231 cell proliferation even at concentrations lower than that of Doxorubicin (75 µg/ml nizwaside vs. 100 µg/ml Doxorubicin). On the other hand, nizwaside showed relatively weak antioxidant activity with 15 % inhibition. |
X Demographics
The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Oman | 2 | 50% |
| Unknown | 2 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 50% |
| Scientists | 1 | 25% |
| Practitioners (doctors, other healthcare professionals) | 1 | 25% |
Mendeley readers
The data shown below were compiled from readership statistics for 18 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Chile | 1 | 6% |
| Unknown | 17 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 4 | 22% |
| Other | 2 | 11% |
| Librarian | 1 | 6% |
| Lecturer > Senior Lecturer | 1 | 6% |
| Unspecified | 1 | 6% |
| Other | 4 | 22% |
| Unknown | 5 | 28% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemistry | 3 | 17% |
| Unspecified | 1 | 6% |
| Biochemistry, Genetics and Molecular Biology | 1 | 6% |
| Pharmacology, Toxicology and Pharmaceutical Science | 1 | 6% |
| Agricultural and Biological Sciences | 1 | 6% |
| Other | 1 | 6% |
| Unknown | 10 | 56% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 November 2015.
All research outputs
#7,727,497
of 24,858,211 outputs
Outputs from Archives of Pharmacal Research
#372
of 1,361 outputs
Outputs of similar age
#85,054
of 272,601 outputs
Outputs of similar age from Archives of Pharmacal Research
#9
of 20 outputs
Altmetric has tracked 24,858,211 research outputs across all sources so far. This one has received more attention than most of these and is in the 68th percentile.
So far Altmetric has tracked 1,361 research outputs from this source. They receive a mean Attention Score of 4.7. This one has gotten more attention than average, scoring higher than 72% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 272,601 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 68% of its contemporaries.
We're also able to compare this research output to 20 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 60% of its contemporaries.