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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Enhancing enterocyte fatty acid oxidation in mice affects glycemic control depending on dietary fat
|
|---|---|
| Published in |
Scientific Reports, July 2018
|
| DOI | 10.1038/s41598-018-29139-6 |
| Pubmed ID | |
| Authors |
Deepti Ramachandran, Rosmarie Clara, Shahana Fedele, Ladina Michel, Johannes Burkard, Sharon Kaufman, Abdiel Alvarado Diaz, Nadja Weissfeld, Katrien De Bock, Carina Prip-Buus, Wolfgang Langhans, Abdelhak Mansouri |
| Abstract |
Studies indicate that modulating enterocyte metabolism might affect whole body glucose homeostasis and the development of diet-induced obesity (DIO). We tested whether enhancing enterocyte fatty acid oxidation (FAO) could protect mice from DIO and impaired glycemic control. To this end, we used mice expressing a mutant form of carnitine palmitoyltransferase-1a (CPT1mt), insensitive to inhibition by malonyl-CoA, in their enterocytes (iCPT1mt) and fed them low-fat control diet (CD) or high-fat diet (HFD) chronically. CPT1mt expression led to an upregulation of FAO in the enterocytes. On CD, iCPT1mt mice had impaired glycemic control and showed concomitant activation of lipogenesis, glycolysis and gluconeogenesis in their enterocytes. On HFD, both iCPT1mt and control mice developed DIO, but iCPT1mt mice showed improved glycemic control and reduced visceral fat mass. Together these data indicate that modulating enterocyte metabolism in iCPT1mt mice affects glycemic control in a body weight-independent, but dietary fat-dependent manner. |
X Demographics
The data shown below were collected from the profiles of 20 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 4 | 20% |
| Spain | 4 | 20% |
| United States | 3 | 15% |
| Germany | 1 | 5% |
| Ecuador | 1 | 5% |
| France | 1 | 5% |
| Belgium | 1 | 5% |
| Czechia | 1 | 5% |
| Canada | 1 | 5% |
| Other | 0 | 0% |
| Unknown | 3 | 15% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 8 | 40% |
| Scientists | 8 | 40% |
| Practitioners (doctors, other healthcare professionals) | 3 | 15% |
| Science communicators (journalists, bloggers, editors) | 1 | 5% |
Mendeley readers
The data shown below were compiled from readership statistics for 33 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 33 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 7 | 21% |
| Researcher | 6 | 18% |
| Student > Master | 5 | 15% |
| Student > Doctoral Student | 2 | 6% |
| Professor > Associate Professor | 2 | 6% |
| Other | 4 | 12% |
| Unknown | 7 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 7 | 21% |
| Biochemistry, Genetics and Molecular Biology | 6 | 18% |
| Immunology and Microbiology | 2 | 6% |
| Medicine and Dentistry | 2 | 6% |
| Computer Science | 2 | 6% |
| Other | 3 | 9% |
| Unknown | 11 | 33% |
Attention Score in Context
This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 July 2018.
All research outputs
#3,481,075
of 25,732,188 outputs
Outputs from Scientific Reports
#29,794
of 142,685 outputs
Outputs of similar age
#62,481
of 323,943 outputs
Outputs of similar age from Scientific Reports
#815
of 3,565 outputs
Altmetric has tracked 25,732,188 research outputs across all sources so far. Compared to these this one has done well and is in the 86th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 142,685 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 18.8. This one has done well, scoring higher than 78% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 323,943 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 80% of its contemporaries.
We're also able to compare this research output to 3,565 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 76% of its contemporaries.