| Title |
Temporal muscle thickness is an independent prognostic marker in melanoma patients with newly diagnosed brain metastases
|
|---|---|
| Published in |
Journal of Neuro-Oncology, July 2018
|
| DOI | 10.1007/s11060-018-2948-8 |
| Pubmed ID | |
| Authors |
Julia Furtner, Anna S. Berghoff, Veronika Schöpf, Robert Reumann, Benjamin Pascher, Ramona Woitek, Ulrika Asenbaum, Sebastian Pelster, Johannes Leitner, Georg Widhalm, Brigitte Gatterbauer, Karin Dieckmann, Christoph Höller, Daniela Prayer, Matthias Preusser |
| Abstract |
The purpose of this study was to evaluate the prognostic relevance of temporal muscle thickness (TMT) in melanoma patients with newly diagnosed brain metastases. TMT was retrospectively assessed in 146 melanoma patients with newly diagnosed brain metastases on cranial magnetic resonance images. Chart review was used to retrieve clinical parameters, including disease-specific graded prognostic assessment (DS-GPA) and survival times. Patients with a TMT > median showed a statistically significant increase in survival time (13 months) compared to patients with a TMT < median (5 months; p < 0.001; log rank test). A Cox regression model revealed that the risk of death was increased by 27.9% with every millimeter reduction in TMT. In the multivariate analysis, TMT (HR 0.724; 95% 0.642-0.816; < 0.001) and DS-GPA (HR 1.214; 95% CI 1.023-1.439; p = 0.026) showed a statistically significant correlation with overall survival. TMT is an independent predictor of survival in melanoma patients with brain metastases. This parameter may aid in patient selection for clinical trials or to the choice of different treatment options based on the determination of frail patient populations. |
X Demographics
The data shown below were collected from the profiles of 24 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 12 | 50% |
| Mexico | 1 | 4% |
| Japan | 1 | 4% |
| Ireland | 1 | 4% |
| Unknown | 9 | 38% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 17 | 71% |
| Scientists | 3 | 13% |
| Practitioners (doctors, other healthcare professionals) | 2 | 8% |
| Science communicators (journalists, bloggers, editors) | 2 | 8% |
Mendeley readers
The data shown below were compiled from readership statistics for 64 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 64 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 12 | 19% |
| Researcher | 11 | 17% |
| Other | 6 | 9% |
| Student > Doctoral Student | 6 | 9% |
| Student > Postgraduate | 4 | 6% |
| Other | 8 | 13% |
| Unknown | 17 | 27% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 22 | 34% |
| Neuroscience | 4 | 6% |
| Unspecified | 3 | 5% |
| Psychology | 3 | 5% |
| Biochemistry, Genetics and Molecular Biology | 1 | 2% |
| Other | 4 | 6% |
| Unknown | 27 | 42% |
Attention Score in Context
This research output has an Altmetric Attention Score of 15. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 February 2019.
All research outputs
#2,449,102
of 25,706,302 outputs
Outputs from Journal of Neuro-Oncology
#133
of 3,279 outputs
Outputs of similar age
#47,791
of 341,112 outputs
Outputs of similar age from Journal of Neuro-Oncology
#2
of 74 outputs
Altmetric has tracked 25,706,302 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 90th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,279 research outputs from this source. They receive a mean Attention Score of 4.5. This one has done particularly well, scoring higher than 95% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 341,112 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 85% of its contemporaries.
We're also able to compare this research output to 74 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 97% of its contemporaries.