| Title |
An increased body mass index is associated with a worse prognosis in patients administered BCG immunotherapy for T1 bladder cancer
|
|---|---|
| Published in |
World Journal of Urology, July 2018
|
| DOI | 10.1007/s00345-018-2397-1 |
| Pubmed ID | |
| Authors |
Matteo Ferro, Mihai Dorin Vartolomei, Giorgio Ivan Russo, Francesco Cantiello, Abdal Rahman Abu Farhan, Daniela Terracciano, Amelia Cimmino, Savino Di Stasi, Gennaro Musi, Rodolfo Hurle, Vincenzo Serretta, Gian Maria Busetto, Ettore De Berardinis, Antonio Cioffi, Sisto Perdonà, Marco Borghesi, Riccardo Schiavina, Gabriele Cozzi, Gilberto L. Almeida, Pierluigi Bove, Estevao Lima, Giovanni Grimaldi, Deliu Victor Matei, Nicolae Crisan, Matteo Muto, Paolo Verze, Michele Battaglia, Giorgio Guazzoni, Riccardo Autorino, Giuseppe Morgia, Rocco Damiano, Ottavio de Cobelli, Shahrokh Shariat, Vincenzo Mirone, Giuseppe Lucarelli |
| Abstract |
The body mass index (BMI) may be associated with an increased incidence and aggressiveness of urological cancers. In this study, we aimed to evaluate the impact of the BMI on survival in patients with T1G3 non-muscle-invasive bladder cancer (NMIBC). A total of 1155 T1G3 NMIBC patients from 13 academic institutions were retrospectively reviewed and patients administered adjuvant intravesical Bacillus Calmette-Guérin (BCG) immunotherapy with maintenance were included. Multivariable Cox regression analysis was performed to identify factors predictive of recurrence and progression. After re-TURBT, 288 patients (27.53%) showed residual high-grade NMIBC, while 867 (82.89%) were negative. During follow-up, 678 (64.82%) suffered recurrence, and 303 (30%) progression, 150 (14.34%) died of all causes, and 77 (7.36%) died of bladder cancer. At multivariate analysis, tumor size (hazard ratio [HR]:1.3; p = 0.001), and multifocality (HR:1.24; p = 0.004) were significantly associated with recurrence (c-index for the model:55.98). Overweight (HR: 4; p < 0.001) and obesity (HR:5.33 p < 0.001) were significantly associated with an increased risk of recurrence. Addition of the BMI to a model that included standard clinicopathological factors increased the C-index by 9.9. For progression, we found that tumor size (HR:1.63; p < 0.001), multifocality (HR:1.31; p = 0.01) and concomitant CIS (HR: 2.07; p < 0.001) were significant prognostic factors at multivariate analysis (C-index 63.8). Overweight (HR: 2.52; p < 0.001) and obesity (HR: 2.521 p < 0.001) were significantly associated with an increased risk of progression. Addition of the BMI to a model that included standard clinicopathological factors increased the C-index by 1.9. The BMI could have a relevant role in the clinical management of T1G3 NMIBC, if associated with bladder cancer recurrence and progression. In particular, this anthropometric factor should be taken into account at initial diagnosis and in therapeutic strategy decision making. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 66 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 66 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 11 | 17% |
| Student > Master | 7 | 11% |
| Student > Bachelor | 6 | 9% |
| Other | 6 | 9% |
| Student > Ph. D. Student | 4 | 6% |
| Other | 7 | 11% |
| Unknown | 25 | 38% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 23 | 35% |
| Biochemistry, Genetics and Molecular Biology | 4 | 6% |
| Pharmacology, Toxicology and Pharmaceutical Science | 3 | 5% |
| Environmental Science | 1 | 2% |
| Sports and Recreations | 1 | 2% |
| Other | 3 | 5% |
| Unknown | 31 | 47% |
Attention Score in Context
This research output has an Altmetric Attention Score of 11. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 September 2018.
All research outputs
#2,924,573
of 23,096,849 outputs
Outputs from World Journal of Urology
#234
of 2,117 outputs
Outputs of similar age
#60,799
of 326,353 outputs
Outputs of similar age from World Journal of Urology
#6
of 59 outputs
Altmetric has tracked 23,096,849 research outputs across all sources so far. Compared to these this one has done well and is in the 87th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,117 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.1. This one has done well, scoring higher than 88% of its peers.
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We're also able to compare this research output to 59 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 89% of its contemporaries.