| Title |
Mrc1/Claspin: a new role for regulation of origin firing
|
|---|---|
| Published in |
Current Genetics, March 2017
|
| DOI | 10.1007/s00294-017-0690-y |
| Pubmed ID | |
| Authors |
Hisao Masai, Chi-Chun Yang, Seiji Matsumoto |
| Abstract |
Mrc1 and its vertebrate homologue Claspin serve as a mediator for replication stress checkpoint signaling, receiving the signal from Mec1/Rad3/ATR sensor kinase and transmitting it to the effector Rad53/Cds1/Chk1 kinase. They are likely to be a part of the replisome and facilitate the S-phase progression by promoting replication fork progression. Recent reports on Mrc1/Claspin indicate their new role in regulating the replication initiation through interaction with Cdc7, a key conserved serine-threonine kinase that triggers firing at each replication origin. Mrc1/Claspin has a specific domain that specifically interacts with Cdc7, and this domain is involved also in intramolecular interaction with its N-terminal segment. Mechanisms for novel regulation of origin firing and its timing through recruitment of Cdc7 to Mrc1/Claspin will be discussed. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| France | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 38 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 38 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 10 | 26% |
| Student > Bachelor | 6 | 16% |
| Professor | 4 | 11% |
| Student > Doctoral Student | 2 | 5% |
| Student > Postgraduate | 2 | 5% |
| Other | 6 | 16% |
| Unknown | 8 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 13 | 34% |
| Agricultural and Biological Sciences | 12 | 32% |
| Medicine and Dentistry | 2 | 5% |
| Immunology and Microbiology | 1 | 3% |
| Unspecified | 1 | 3% |
| Other | 0 | 0% |
| Unknown | 9 | 24% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 July 2018.
All research outputs
#20,527,576
of 23,096,849 outputs
Outputs from Current Genetics
#1,058
of 1,204 outputs
Outputs of similar age
#269,435
of 309,024 outputs
Outputs of similar age from Current Genetics
#12
of 14 outputs
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