Title |
Acute kidney injury in patients with cirrhosis of liver: Clinical profile and predictors of outcome
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Published in |
Indian Journal of Gastroenterology, July 2018
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DOI | 10.1007/s12664-018-0867-4 |
Pubmed ID | |
Authors |
Shiran Shetty, Shankar Prasad Nagaraju, Srinivas Shenoy, Ravindra Prabhu Attur, Dharshan Rangaswamy, Indu R. Rao, Uday Venkat Mateti, Rajeevalochana Parthasarathy |
Abstract |
Acute kidney injury (AKI) is a common complication of liver cirrhosis and is associated with poor survival. We studied the clinical profile and predictors of in-hospital mortality in patients with cirrhosis of the liver with AKI. This retrospective cohort study examined patients at a tertiary care hospital. AKI staging was done based on the new 2015 Ascites Club Criteria. Patients were grouped into three types of AKI: pre-renal azotemia (PRA), hepatorenal syndrome (HRS), and acute tubular necrosis (ATN). Data of 123 patients with cirrhosis and AKI were analyzed. Most patients had AKI stage 3 (57.7%). ATN (42.3%) and HRS (43.9) were the predominant types of AKI followed by PRA (13.8%). The overall in-hospital mortality in our study was 44.7%. The mortality increased with increasing severity of AKI (p = 0.0001) and was the highest in AKI stage 3 (p = 0.001) and those who required hemodialysis (p = 0.001). There was a significant in-hospital mortality in patients with ATN and HRS in comparison to PRA (p = 0.001). On multivariate analysis, the factors predicting in-hospital mortality were AKI stage 3, and oliguria (p = 0.0001). Acute kidney injury in cirrhosis of liver carries high in-hospital mortality. Pre-renal AKI has a better survival compared to ATN and HRS. The higher stage of AKI at presentation and the presence of oliguria are two important predictors of in-hospital mortality. |
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Unknown | 1 | 100% |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 32 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 6 | 19% |
Student > Bachelor | 5 | 16% |
Student > Postgraduate | 4 | 13% |
Unspecified | 3 | 9% |
Student > Master | 1 | 3% |
Other | 1 | 3% |
Unknown | 12 | 38% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 12 | 38% |
Unspecified | 3 | 9% |
Biochemistry, Genetics and Molecular Biology | 1 | 3% |
Immunology and Microbiology | 1 | 3% |
Nursing and Health Professions | 1 | 3% |
Other | 0 | 0% |
Unknown | 14 | 44% |