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Polyketides and Alkaloids from the Marine-Derived Fungus Dichotomomyces cejpii F31-1 and the Antiviral Activity of Scequinadoline A against Dengue Virus

Overview of attention for article published in Marine Drugs, July 2018
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Title
Polyketides and Alkaloids from the Marine-Derived Fungus Dichotomomyces cejpii F31-1 and the Antiviral Activity of Scequinadoline A against Dengue Virus
Published in
Marine Drugs, July 2018
DOI 10.3390/md16070229
Pubmed ID
Authors

Dong-Lan Wu, Hou-Jin Li, Duncan R. Smith, Janejira Jaratsittisin, Xia-Fu-Kai-Ti Xia-Ke-Er, Wen-Zhe Ma, Yong-Wei Guo, Jun Dong, Juan Shen, De-Po Yang, Wen-Jian Lan

Abstract

In our continuous chemical investigation on the marine-derived fungus Dichotomomyces cejpii F31-1, two new polyketides dichocetides B-C (1, 2), two new alkaloids dichotomocejs E-F (3, 4), and three known fumiquinozalines: scequinadoline A (5), quinadoline A (6), and scequinadoline E (7) were discovered from the culture broth and the mycelium in the culture medium, by the addition of l-tryptophan and l-phenylalanine. Their chemical structures were established by one dimensional (1D), two dimensional (2D) nuclear magnetic resonance (NMR) and high resolution mass spectrometry (HR-MS) data. Among them, scequinadoline A (5) exhibited significant inhibitory activity against dengue virus serotype 2 production by standard plaque assay, equivalent to the positive control andrographlide. Scequinadoline A (5) possesses the potential for further development as a dengue virus inhibitor.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 30 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 30 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 5 17%
Student > Master 4 13%
Student > Ph. D. Student 3 10%
Student > Doctoral Student 2 7%
Student > Bachelor 2 7%
Other 3 10%
Unknown 11 37%
Readers by discipline Count As %
Chemistry 6 20%
Biochemistry, Genetics and Molecular Biology 5 17%
Medicine and Dentistry 4 13%
Agricultural and Biological Sciences 3 10%
Chemical Engineering 1 3%
Other 1 3%
Unknown 10 33%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 July 2018.
All research outputs
#15,540,879
of 23,096,849 outputs
Outputs from Marine Drugs
#1,998
of 3,605 outputs
Outputs of similar age
#209,171
of 327,719 outputs
Outputs of similar age from Marine Drugs
#52
of 80 outputs
Altmetric has tracked 23,096,849 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,605 research outputs from this source. They receive a mean Attention Score of 4.6. This one is in the 33rd percentile – i.e., 33% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 327,719 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 27th percentile – i.e., 27% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 80 others from the same source and published within six weeks on either side of this one. This one is in the 27th percentile – i.e., 27% of its contemporaries scored the same or lower than it.