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α-Toxin Induces Platelet Aggregation and Liver Injury during Staphylococcus aureus Sepsis

Overview of attention for article published in Cell Host & Microbe (Science Direct), July 2018
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  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (96th percentile)
  • Good Attention Score compared to outputs of the same age and source (77th percentile)

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6 news outlets
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48 X users
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1 patent

Citations

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105 Dimensions

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152 Mendeley
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Title
α-Toxin Induces Platelet Aggregation and Liver Injury during Staphylococcus aureus Sepsis
Published in
Cell Host & Microbe (Science Direct), July 2018
DOI 10.1016/j.chom.2018.06.017
Pubmed ID
Authors

Bas G.J. Surewaard, Ajitha Thanabalasuriar, Zhutian Zeng, Christine Tkaczyk, Taylor S. Cohen, Bart W. Bardoel, Selina K. Jorch, Carsten Deppermann, Juliane Bubeck Wardenburg, Rachelle P. Davis, Craig N. Jenne, Kendall C. Stover, Bret R. Sellman, Paul Kubes

Abstract

During sepsis, small blood vessels can become occluded by large platelet aggregates of poorly understood etiology. During Staphylococcal aureus infection, sepsis severity is linked to the bacterial α-toxin (α-hemolysin, AT) through unclear mechanisms. In this study, we visualized intravascular events in the microcirculation and found that intravenous AT injection induces rapid platelet aggregation, forming dynamic micro-thrombi in the microcirculation. These aggregates are retained in the liver sinusoids and kidney glomeruli, causing multi-organ dysfunction. Acute staphylococcal infection results in sequestration of most bacteria by liver macrophages. Platelets are initially recruited to these macrophages and help eradicate S. aureus. However, at later time points, AT causes aberrant and damaging thrombosis throughout the liver. Treatment with an AT neutralizing antibody (MEDI4893∗) prevents platelet aggregation and subsequent liver damage, without affecting the initial and beneficial platelet recruitment. Thus, AT neutralization may represent a promising approach to combat staphylococcal-induced intravascular coagulation and organ dysfunction.

X Demographics

X Demographics

The data shown below were collected from the profiles of 48 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 152 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 152 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 28 18%
Student > Bachelor 22 14%
Student > Master 18 12%
Researcher 17 11%
Professor 6 4%
Other 18 12%
Unknown 43 28%
Readers by discipline Count As %
Immunology and Microbiology 29 19%
Biochemistry, Genetics and Molecular Biology 26 17%
Agricultural and Biological Sciences 18 12%
Medicine and Dentistry 12 8%
Pharmacology, Toxicology and Pharmaceutical Science 3 2%
Other 16 11%
Unknown 48 32%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 71. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 November 2021.
All research outputs
#598,802
of 25,385,509 outputs
Outputs from Cell Host & Microbe (Science Direct)
#446
of 2,627 outputs
Outputs of similar age
#12,840
of 340,393 outputs
Outputs of similar age from Cell Host & Microbe (Science Direct)
#12
of 53 outputs
Altmetric has tracked 25,385,509 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,627 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 51.6. This one has done well, scoring higher than 83% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 340,393 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 96% of its contemporaries.
We're also able to compare this research output to 53 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 77% of its contemporaries.