Title |
The treatment of severe child aggression (TOSCA) study: Design challenges
|
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Published in |
Child and Adolescent Psychiatry and Mental Health, November 2011
|
DOI | 10.1186/1753-2000-5-36 |
Pubmed ID | |
Authors |
Cristan A Farmer, L Eugene Arnold, Oscar G Bukstein, Robert L Findling, Kenneth D Gadow, Xiaobai Li, Eric M Butter, Michael G Aman |
Abstract |
Polypharmacy (the concurrent use of more than one psychoactive drug) and other combination interventions are increasingly common for treatment of severe psychiatric problems only partly responsive to monotherapy. This practice and research on it raise scientific, clinical, and ethical issues such as additive side effects, interactions, threshold for adding second drug, appropriate target measures, and (for studies) timing of randomization. One challenging area for treatment is severe child aggression. Commonly-used medications, often in combination, include psychostimulants, antipsychotics, mood stabilizers, and alpha-2 agonists, which vary considerably in terms of perceived safety and efficacy. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Germany | 1 | 1% |
Italy | 1 | 1% |
Brazil | 1 | 1% |
South Africa | 1 | 1% |
United States | 1 | 1% |
Unknown | 90 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 17 | 18% |
Student > Master | 15 | 16% |
Researcher | 9 | 9% |
Student > Bachelor | 9 | 9% |
Student > Doctoral Student | 9 | 9% |
Other | 19 | 20% |
Unknown | 17 | 18% |
Readers by discipline | Count | As % |
---|---|---|
Psychology | 27 | 28% |
Medicine and Dentistry | 26 | 27% |
Social Sciences | 5 | 5% |
Nursing and Health Professions | 4 | 4% |
Agricultural and Biological Sciences | 4 | 4% |
Other | 10 | 11% |
Unknown | 19 | 20% |