| Title |
Sex differences in the association between diabetes and cancer: a systematic review and meta-analysis of 121 cohorts including 20 million individuals and one million events
|
|---|---|
| Published in |
Diabetologia, July 2018
|
| DOI | 10.1007/s00125-018-4664-5 |
| Pubmed ID | |
| Authors |
Toshiaki Ohkuma, Sanne A. E. Peters, Mark Woodward |
| Abstract |
Diabetes has been shown to be a risk factor for some cancers. Whether diabetes confers the same excess risk of cancer, overall and by site, in women and men is unknown. A systematic search was performed in PubMed for cohort studies published up to December 2016. Selected studies reported sex-specific relative risk (RR) estimates for the association between diabetes and cancer adjusted at least for age in both sexes. Random-effects meta-analyses with inverse-variance weighting were used to obtain pooled sex-specific RRs and women-to-men ratios of RRs (RRRs) for all-site and site-specific cancers. Data on all-site cancer events (incident or fatal only) were available from 121 cohorts (19,239,302 individuals; 1,082,592 events). The pooled adjusted RR for all-site cancer associated with diabetes was 1.27 (95% CI 1.21, 1.32) in women and 1.19 (1.13, 1.25) in men. Women with diabetes had ~6% greater risk compared with men with diabetes (the pooled RRR was 1.06, 95% CI 1.03, 1.09). Corresponding pooled RRRs were 1.10 (1.07, 1.13) for all-site cancer incidence and 1.03 (0.99, 1.06) for all-site cancer mortality. Diabetes also conferred a significantly greater RR in women than men for oral, stomach and kidney cancer, and for leukaemia, but a lower RR for liver cancer. Diabetes is a risk factor for all-site cancer for both women and men, but the excess risk of cancer associated with diabetes is slightly greater for women than men. The direction and magnitude of sex differences varies by location of the cancer. |
X Demographics
The data shown below were collected from the profiles of 106 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 12 | 11% |
| United Kingdom | 10 | 9% |
| United States | 9 | 8% |
| France | 7 | 7% |
| Canada | 6 | 6% |
| Mexico | 4 | 4% |
| Germany | 2 | 2% |
| Brazil | 2 | 2% |
| Italy | 2 | 2% |
| Other | 14 | 13% |
| Unknown | 38 | 36% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 70 | 66% |
| Practitioners (doctors, other healthcare professionals) | 19 | 18% |
| Scientists | 15 | 14% |
| Science communicators (journalists, bloggers, editors) | 2 | 2% |
Mendeley readers
The data shown below were compiled from readership statistics for 182 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 182 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 23 | 13% |
| Student > Ph. D. Student | 19 | 10% |
| Student > Master | 17 | 9% |
| Student > Bachelor | 16 | 9% |
| Other | 10 | 5% |
| Other | 33 | 18% |
| Unknown | 64 | 35% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 54 | 30% |
| Agricultural and Biological Sciences | 9 | 5% |
| Biochemistry, Genetics and Molecular Biology | 9 | 5% |
| Nursing and Health Professions | 7 | 4% |
| Pharmacology, Toxicology and Pharmaceutical Science | 5 | 3% |
| Other | 23 | 13% |
| Unknown | 75 | 41% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1054. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 March 2022.
All research outputs
#15,129
of 25,774,185 outputs
Outputs from Diabetologia
#8
of 5,381 outputs
Outputs of similar age
#282
of 341,187 outputs
Outputs of similar age from Diabetologia
#1
of 64 outputs
Altmetric has tracked 25,774,185 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,381 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 25.1. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 341,187 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 64 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 98% of its contemporaries.