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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Combinatorial Contact Cues Specify Cell Division Orientation by Directing Cortical Myosin Flows
|
|---|---|
| Published in |
Developmental Cell, July 2018
|
| DOI | 10.1016/j.devcel.2018.06.020 |
| Pubmed ID | |
| Authors |
Kenji Sugioka, Bruce Bowerman |
| Abstract |
Cell division axes during development are specified in different orientations to establish multicellular assemblies, but the mechanisms that generate division axis diversity remain unclear. We show here that patterns of cell contact provide cues that diversify cell division orientation by modulating cortical non-muscle myosin flow. We reconstituted in vivo contact patterns using beads or isolated cells to show two findings. First, we identified three contact-dependent cues that pattern cell division orientation and myosin flow: physical contact, contact asymmetry, and a Wnt signal. Second, we experimentally demonstrated that myosin flow generates forces that trigger plasma membrane movements and propose that their anisotropy drives cell division orientation. Our data suggest that contact-dependent control of myosin specifies the division axes of Caenorhabditis elegans AB, ABa, EMS cells, and the mouse AB cell. The contact pattern-dependent generation of myosin flows, in concert with known microtubule/dynein pathways, may greatly expand division axis diversity during development. |
X Demographics
The data shown below were collected from the profiles of 100 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 26 | 26% |
| United Kingdom | 8 | 8% |
| Canada | 7 | 7% |
| India | 5 | 5% |
| Japan | 5 | 5% |
| Germany | 4 | 4% |
| Australia | 3 | 3% |
| Netherlands | 2 | 2% |
| New Zealand | 2 | 2% |
| Other | 6 | 6% |
| Unknown | 32 | 32% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 61 | 61% |
| Scientists | 37 | 37% |
| Practitioners (doctors, other healthcare professionals) | 2 | 2% |
Mendeley readers
The data shown below were compiled from readership statistics for 109 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 109 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 28 | 26% |
| Researcher | 17 | 16% |
| Student > Bachelor | 14 | 13% |
| Student > Master | 7 | 6% |
| Student > Doctoral Student | 5 | 5% |
| Other | 15 | 14% |
| Unknown | 23 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 43 | 39% |
| Agricultural and Biological Sciences | 21 | 19% |
| Physics and Astronomy | 4 | 4% |
| Engineering | 3 | 3% |
| Neuroscience | 3 | 3% |
| Other | 9 | 8% |
| Unknown | 26 | 24% |
Attention Score in Context
This research output has an Altmetric Attention Score of 58. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 October 2018.
All research outputs
#743,720
of 25,750,437 outputs
Outputs from Developmental Cell
#299
of 4,367 outputs
Outputs of similar age
#15,617
of 341,460 outputs
Outputs of similar age from Developmental Cell
#7
of 67 outputs
Altmetric has tracked 25,750,437 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,367 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 17.2. This one has done particularly well, scoring higher than 93% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 341,460 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 95% of its contemporaries.
We're also able to compare this research output to 67 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 89% of its contemporaries.