| Title |
Chromosomal abnormalities and Y chromosome microdeletions in infertile men from Morocco
|
|---|---|
| Published in |
BMC Urology, September 2015
|
| DOI | 10.1186/s12894-015-0089-3 |
| Pubmed ID | |
| Authors |
Yassine Naasse, Hicham Charoute, Brahim El Houate, Chadli Elbekkay, Lunda Razoki, Abderrahim Malki, Abdelhamid Barakat, Hassan Rouba |
| Abstract |
Male infertility is responsible for 50 % of infertile couples. Thirty percent of male infertility is due to cytogenetic and genetic abnormalities. In Arab and North African populations, several studies have shown the association of these chromosomal abnormalities with male infertility. Our objective is to evaluate the frequency of chromosomal abnormalities and Y chromosome microdeletions in infertile men from Morocco. A total of 573 Moroccan infertile men (444 azoospermic and 129 oligozoospermic men) referred for cytogenetic analysis to the Department of Cytogenetics of the Pasteur Institute of Morocco, were screened for the presence of chromosomal abnormalities and Y chromosome microdeletions. Chromosomal abnormalities accounted for approximately 10.5 % (60/573). Fifty six cases among them have sex chromosome abnormalities (93.34 %), including Klinefelter's syndrome in 41 patients (68.34 %). Autosomal chromosome abnormalities (6.66 %) were observed in 4 patients. Chromosomal abnormalities were more prevalent in azoospermic men (13.06 %) than in oligospermic men (1.55 %). Y microdeletions were detected in 16 of 85 patients (AZFc: 14.12 %, AZFbc: 4.70 %), most of them where azoospermic men with no chromosomal abnormality. These results highlighted the need for efficient molecular genetic testing in male infertility diagnosis. In addition, a genetic screening should be performed in infertile men before starting assisted reproductive treatments. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 33% |
| Unknown | 2 | 67% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 67% |
| Scientists | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 52 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 52 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 9 | 17% |
| Student > Bachelor | 7 | 13% |
| Student > Ph. D. Student | 5 | 10% |
| Researcher | 4 | 8% |
| Student > Doctoral Student | 3 | 6% |
| Other | 7 | 13% |
| Unknown | 17 | 33% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 12 | 23% |
| Biochemistry, Genetics and Molecular Biology | 11 | 21% |
| Agricultural and Biological Sciences | 7 | 13% |
| Social Sciences | 1 | 2% |
| Immunology and Microbiology | 1 | 2% |
| Other | 2 | 4% |
| Unknown | 18 | 35% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 September 2015.
All research outputs
#14,175,907
of 22,829,083 outputs
Outputs from BMC Urology
#347
of 751 outputs
Outputs of similar age
#139,903
of 272,855 outputs
Outputs of similar age from BMC Urology
#4
of 11 outputs
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We're also able to compare this research output to 11 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 63% of its contemporaries.