| Title |
Association between magnesium intake and risk of colorectal cancer among postmenopausal women
|
|---|---|
| Published in |
Cancer Causes & Control, September 2015
|
| DOI | 10.1007/s10552-015-0669-2 |
| Pubmed ID | |
| Authors |
Anna M. Gorczyca, Ka He, Pencheng Xun, Karen L. Margolis, Janet P. Wallace, Dorothy Lane, Cynthia Thomson, Gloria Y. F. Ho, James M. Shikany, Juhua Luo |
| Abstract |
Data relating to magnesium intake and colorectal cancer (CRC) risk in postmenopausal women are incomplete. We investigated the association between total magnesium intake and the risk of CRC in an ethnically diverse cohort of postmenopausal women enrolled in the Women's Health Initiative. Self-reported dietary and supplemental magnesium were combined to form total magnesium intake. Invasive incident CRC was the primary outcome. Cox proportional hazard models were used to estimate hazard ratios (HRs) and 95 % confidence intervals (CI). During an average follow-up of 13 years (1,832,319 person-years), of the 140,601 women included for analysis, 2,381 women were diagnosed with CRC (1,982 colon cancer and 438 rectal cancer). After adjustment for potential confounding variables, an inverse association was observed in the highest quintile of total magnesium intake compared to the lowest quintile for risk of CRC (HR 0.79, 95 % CI 0.67, 0.94, p trend < 0.0001) and colon cancer (HR 0.80, 95 % CI 0.66, 0.97, p trend < 0.0001). A borderline significant inverse association was detected in the highest versus the lowest quintile of total magnesium intake for rectal cancer (HR 0.76, 95 % CI 0.51, 1.13, p trend < 0.001). Findings from this study support the hypothesis that magnesium intake around 400 mg/day from both dietary and supplemental sources is associated with a lower incidence of CRC in postmenopausal women. |
X Demographics
The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 60% |
| India | 1 | 20% |
| Unknown | 1 | 20% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 80% |
| Scientists | 1 | 20% |
Mendeley readers
The data shown below were compiled from readership statistics for 29 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 29 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Other | 5 | 17% |
| Student > Bachelor | 3 | 10% |
| Student > Master | 3 | 10% |
| Librarian | 2 | 7% |
| Student > Ph. D. Student | 2 | 7% |
| Other | 3 | 10% |
| Unknown | 11 | 38% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 8 | 28% |
| Nursing and Health Professions | 5 | 17% |
| Agricultural and Biological Sciences | 2 | 7% |
| Unspecified | 1 | 3% |
| Social Sciences | 1 | 3% |
| Other | 1 | 3% |
| Unknown | 11 | 38% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 December 2015.
All research outputs
#7,916,538
of 23,854,458 outputs
Outputs from Cancer Causes & Control
#950
of 2,187 outputs
Outputs of similar age
#94,851
of 277,555 outputs
Outputs of similar age from Cancer Causes & Control
#11
of 33 outputs
Altmetric has tracked 23,854,458 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,187 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.2. This one is in the 36th percentile – i.e., 36% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 277,555 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 56% of its contemporaries.
We're also able to compare this research output to 33 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 57% of its contemporaries.