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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Impaired Mitophagy and Protein Acetylation Levels in Fibroblasts from Parkinson’s Disease Patients
|
|---|---|
| Published in |
Molecular Neurobiology, July 2018
|
| DOI | 10.1007/s12035-018-1206-6 |
| Pubmed ID | |
| Authors |
Sokhna M. S. Yakhine-Diop, Mireia Niso-Santano, Mario Rodríguez-Arribas, Rubén Gómez-Sánchez, Guadalupe Martínez-Chacón, Elisabet Uribe-Carretero, José A. Navarro-García, Gema Ruiz-Hurtado, Ana Aiastui, J. Mark Cooper, Adolfo López de Munaín, José M. Bravo-San Pedro, Rosa A. González-Polo, José M. Fuentes |
| Abstract |
Parkinson's disease (PD) is a chronic and progressive neurodegenerative disorder. While most PD cases are idiopathic, the known genetic causes of PD are useful to understand common disease mechanisms. Recent data suggests that autophagy is regulated by protein acetylation mediated by histone acetyltransferase (HAT) and histone deacetylase (HDAC) activities. The changes in histone acetylation reported to be involved in PD pathogenesis have prompted this investigation of protein acetylation and HAT and HDAC activities in both idiopathic PD and G2019S leucine-rich repeat kinase 2 (LRRK2) cell cultures. Fibroblasts from PD patients (with or without the G2019S LRRK2 mutation) and control subjects were used to assess the different phenotypes between idiopathic and genetic PD. G2019S LRRK2 mutation displays increased mitophagy due to the activation of class III HDACs whereas idiopathic PD exhibits downregulation of clearance of defective mitochondria. This reduction of mitophagy is accompanied by more reactive oxygen species (ROS). In parallel, the acetylation protein levels of idiopathic and genetic individuals are different due to an upregulation in class I and II HDACs. Despite this upregulation, the total HDAC activity is decreased in idiopathic PD and the total HAT activity does not significantly vary. Mitophagy upregulation is beneficial for reducing the ROS-induced harm in genetic PD. The defective mitophagy in idiopathic PD is inherent to the decrease in class III HDACs. Thus, there is an imbalance between total HATs and HDACs activities in idiopathic PD, which increases cell death. The inhibition of HATs in idiopathic PD cells displays a cytoprotective effect. |
X Demographics
The data shown below were collected from the profiles of 13 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 5 | 38% |
| United States | 1 | 8% |
| Canada | 1 | 8% |
| Austria | 1 | 8% |
| Unknown | 5 | 38% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 9 | 69% |
| Scientists | 3 | 23% |
| Science communicators (journalists, bloggers, editors) | 1 | 8% |
Mendeley readers
The data shown below were compiled from readership statistics for 79 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 79 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 12 | 15% |
| Student > Master | 11 | 14% |
| Student > Bachelor | 11 | 14% |
| Researcher | 6 | 8% |
| Student > Doctoral Student | 5 | 6% |
| Other | 9 | 11% |
| Unknown | 25 | 32% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 19 | 24% |
| Neuroscience | 10 | 13% |
| Agricultural and Biological Sciences | 6 | 8% |
| Medicine and Dentistry | 5 | 6% |
| Pharmacology, Toxicology and Pharmaceutical Science | 3 | 4% |
| Other | 9 | 11% |
| Unknown | 27 | 34% |
Attention Score in Context
This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 July 2019.
All research outputs
#4,633,504
of 23,096,849 outputs
Outputs from Molecular Neurobiology
#1,094
of 3,498 outputs
Outputs of similar age
#88,329
of 329,030 outputs
Outputs of similar age from Molecular Neurobiology
#50
of 147 outputs
Altmetric has tracked 23,096,849 research outputs across all sources so far. Compared to these this one has done well and is in the 79th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,498 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.2. This one has gotten more attention than average, scoring higher than 68% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 329,030 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 73% of its contemporaries.
We're also able to compare this research output to 147 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 65% of its contemporaries.