| Title |
Proliferation, Migration, and Production of Nitric Oxide by Bone Marrow Multipotent Mesenchymal Stromal Cells from Wistar Rats in Hypoxia and Hyperglycemia
|
|---|---|
| Published in |
Bulletin of Experimental Biology and Medicine, September 2015
|
| DOI | 10.1007/s10517-015-2986-6 |
| Pubmed ID | |
| Authors |
A. P. Lykov, Yu. V. Nikonorova, N. A. Bondarenko, O. V. Poveshchenko, I. I. Kim, A. F. Poveshchenko, V. I. Konenkov |
| Abstract |
We studied proliferation, migration, and secretion of NO by bone marrow multipotent mesenchymal stromal cells from Wistar rats during conditioning under hypoxic and hyperglycemic conditions and the effect of erythropoietin on these parameters. A stimulating effect of erythropoietin on cell proliferation under normal conditions and activation of cell proliferation under conditions of hypoxia and hyperglycemia were demonstrated. Erythropoietin abolishes suppression of cell proliferation in culture with normal glucose level under conditions of H2O2-induced hypoxia, while under conditions of hyperglycemia, inhibition of cell proliferation becomes more pronounced. Hypoxia promotes activation of cell migration along the growth factor concentration gradient and addition of erythropoietin to the nutrient medium leads to a decrease in cell migration activity. Erythropoietin stimulates NO production by cells cultured under the conditions of hypoxia and hyperglycemia. |
X Demographics
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 9 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 9 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 2 | 22% |
| Student > Bachelor | 2 | 22% |
| Student > Doctoral Student | 1 | 11% |
| Student > Ph. D. Student | 1 | 11% |
| Researcher | 1 | 11% |
| Other | 0 | 0% |
| Unknown | 2 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 3 | 33% |
| Biochemistry, Genetics and Molecular Biology | 2 | 22% |
| Sports and Recreations | 1 | 11% |
| Agricultural and Biological Sciences | 1 | 11% |
| Unknown | 2 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 September 2015.
All research outputs
#21,697,638
of 24,217,893 outputs
Outputs from Bulletin of Experimental Biology and Medicine
#931
of 1,357 outputs
Outputs of similar age
#238,102
of 278,741 outputs
Outputs of similar age from Bulletin of Experimental Biology and Medicine
#9
of 28 outputs
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