Title |
Reference range of liver corrected T1 values in a population at low risk for fatty liver disease—a UK Biobank sub-study, with an appendix of interesting cases
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Published in |
Abdominal Radiology, July 2018
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DOI | 10.1007/s00261-018-1701-2 |
Pubmed ID | |
Authors |
A. Mojtahed, C. J. Kelly, A. H. Herlihy, S. Kin, H. R. Wilman, A. McKay, M. Kelly, M. Milanesi, S. Neubauer, E. L. Thomas, J. D. Bell, R. Banerjee, M. Harisinghani |
Abstract |
Corrected T1 (cT1) value is a novel MRI-based quantitative metric for assessing a composite of liver inflammation and fibrosis. It has been shown to distinguish between non-alcoholic fatty liver disease (NAFL) and non-alcoholic steatohepatitis. However, these studies were conducted in patients at high risk for liver disease. This study establishes the normal reference range of cT1 values for a large UK population, and assesses interactions of age and gender. MR data were acquired on a 1.5 T system as part of the UK Biobank Imaging Enhancement study. Measures for Proton Density Fat Fraction and cT1 were calculated from the MRI data using a multiparametric MRI software application. Data that did not meet quality criteria were excluded from further analysis. Inter and intra-reader variability was estimated in a set of data. A cohort at low risk for NAFL was identified by excluding individuals with BMI ≥ 25 kg/m2 and PDFF ≥ 5%. Of the 2816 participants with data of suitable quality, 1037 (37%) were classified as at low risk. The cT1 values in the low-risk population ranged from 573 to 852 ms with a median of 666 ms and interquartile range from 643 to 694 ms. Iron correction of T1 was necessary in 36.5% of this reference population. Age and gender had minimal effect on cT1 values. The majority of cT1 values are tightly clustered in a population at low risk for NAFL, suggesting it has the potential to serve as a new quantitative imaging biomarker for studies of liver health and disease. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 9 | 82% |
United States | 2 | 18% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 8 | 73% |
Practitioners (doctors, other healthcare professionals) | 2 | 18% |
Scientists | 1 | 9% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 90 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 25 | 28% |
Student > Ph. D. Student | 12 | 13% |
Student > Master | 7 | 8% |
Student > Bachelor | 5 | 6% |
Other | 5 | 6% |
Other | 13 | 14% |
Unknown | 23 | 26% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 30 | 33% |
Biochemistry, Genetics and Molecular Biology | 7 | 8% |
Agricultural and Biological Sciences | 5 | 6% |
Computer Science | 5 | 6% |
Engineering | 5 | 6% |
Other | 15 | 17% |
Unknown | 23 | 26% |