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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Targeting stromal remodeling and cancer stem cell plasticity overcomes chemoresistance in triple negative breast cancer
|
|---|---|
| Published in |
Nature Communications, July 2018
|
| DOI | 10.1038/s41467-018-05220-6 |
| Pubmed ID | |
| Authors |
Aurélie S. Cazet, Mun N. Hui, Benjamin L. Elsworth, Sunny Z. Wu, Daniel Roden, Chia-Ling Chan, Joanna N. Skhinas, Raphaël Collot, Jessica Yang, Kate Harvey, M. Zahied Johan, Caroline Cooper, Radhika Nair, David Herrmann, Andrea McFarland, Niantao Deng, Manuel Ruiz-Borrego, Federico Rojo, José M. Trigo, Susana Bezares, Rosalía Caballero, Elgene Lim, Paul Timpson, Sandra O’Toole, D. Neil Watkins, Thomas R. Cox, Michael S. Samuel, Miguel Martín, Alexander Swarbrick |
| Abstract |
The cellular and molecular basis of stromal cell recruitment, activation and crosstalk in carcinomas is poorly understood, limiting the development of targeted anti-stromal therapies. In mouse models of triple negative breast cancer (TNBC), Hedgehog ligand produced by neoplastic cells reprograms cancer-associated fibroblasts (CAFs) to provide a supportive niche for the acquisition of a chemo-resistant, cancer stem cell (CSC) phenotype via FGF5 expression and production of fibrillar collagen. Stromal treatment of patient-derived xenografts with smoothened inhibitors (SMOi) downregulates CSC markers expression and sensitizes tumors to docetaxel, leading to markedly improved survival and reduced metastatic burden. In the phase I clinical trial EDALINE, 3 of 12 patients with metastatic TNBC derived clinical benefit from combination therapy with the SMOi Sonidegib and docetaxel chemotherapy, with one patient experiencing a complete response. These studies identify Hedgehog signaling to CAFs as a novel mediator of CSC plasticity and an exciting new therapeutic target in TNBC. |
X Demographics
The data shown below were collected from the profiles of 51 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Australia | 17 | 33% |
| United States | 5 | 10% |
| United Kingdom | 3 | 6% |
| France | 2 | 4% |
| China | 2 | 4% |
| Switzerland | 1 | 2% |
| Denmark | 1 | 2% |
| South Africa | 1 | 2% |
| Japan | 1 | 2% |
| Other | 1 | 2% |
| Unknown | 17 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 23 | 45% |
| Members of the public | 22 | 43% |
| Science communicators (journalists, bloggers, editors) | 3 | 6% |
| Practitioners (doctors, other healthcare professionals) | 3 | 6% |
Mendeley readers
The data shown below were compiled from readership statistics for 345 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 345 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 78 | 23% |
| Researcher | 41 | 12% |
| Student > Bachelor | 31 | 9% |
| Student > Master | 24 | 7% |
| Student > Doctoral Student | 15 | 4% |
| Other | 44 | 13% |
| Unknown | 112 | 32% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 94 | 27% |
| Medicine and Dentistry | 38 | 11% |
| Agricultural and Biological Sciences | 31 | 9% |
| Pharmacology, Toxicology and Pharmaceutical Science | 15 | 4% |
| Immunology and Microbiology | 14 | 4% |
| Other | 31 | 9% |
| Unknown | 122 | 35% |
Attention Score in Context
This research output has an Altmetric Attention Score of 78. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 September 2020.
All research outputs
#557,486
of 25,635,728 outputs
Outputs from Nature Communications
#9,557
of 57,888 outputs
Outputs of similar age
#11,828
of 341,451 outputs
Outputs of similar age from Nature Communications
#258
of 1,324 outputs
Altmetric has tracked 25,635,728 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 57,888 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 55.5. This one has done well, scoring higher than 83% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 341,451 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 96% of its contemporaries.
We're also able to compare this research output to 1,324 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 80% of its contemporaries.