Title |
Rapid development of cardiac dysfunction in a canine model of insulin resistance and moderate obesity
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Published in |
Diabetologia, September 2015
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DOI | 10.1007/s00125-015-3767-5 |
Pubmed ID | |
Authors |
Josiane L. Broussard, Michael D. Nelson, Cathryn M. Kolka, Isaac Asare Bediako, Rebecca L. Paszkiewicz, Laura Smith, Edward W. Szczepaniak, Darko Stefanovski, Lidia S. Szczepaniak, Richard N. Bergman |
Abstract |
The worldwide incidence of obesity and diabetes continues to rise at an alarming rate. A major cause of the morbidity and mortality associated with obesity and diabetes is heart disease, yet the mechanisms that lead to cardiovascular complications remain unclear. We performed cardiac MRI to assess left ventricular morphology and function during the development of moderate obesity and insulin resistance in a well-established canine model (n = 26). To assess the influence of dietary fat composition, we randomised animals to a traditional lard diet (rich in saturated and monounsaturated fat; n = 12), a salmon oil diet (rich in polyunsaturated fat; n = 8) or a control diet (n = 6). High-fat feeding with lard increased body weight and fasting insulin and markedly reduced insulin sensitivity. Lard feeding also significantly reduced left ventricular function, evidenced by a worsening of circumferential strain and impairment in left ventricular torsion. High-fat feeding with salmon oil increased body weight; however, salmon oil feeding did not impair insulin sensitivity or cardiac function. These data emphasise the importance of dietary fat composition on both metabolic and cardiac function, and have important implications for the relationship between diet and health. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 3 | 38% |
United States | 2 | 25% |
India | 1 | 13% |
Unknown | 2 | 25% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 8 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 5% |
Unknown | 39 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 5 | 12% |
Researcher | 4 | 10% |
Student > Doctoral Student | 4 | 10% |
Student > Master | 4 | 10% |
Other | 2 | 5% |
Other | 8 | 20% |
Unknown | 14 | 34% |
Readers by discipline | Count | As % |
---|---|---|
Veterinary Science and Veterinary Medicine | 9 | 22% |
Medicine and Dentistry | 8 | 20% |
Biochemistry, Genetics and Molecular Biology | 2 | 5% |
Engineering | 2 | 5% |
Psychology | 2 | 5% |
Other | 4 | 10% |
Unknown | 14 | 34% |