| Title |
Haste Makes Waste: The Interplay Between Dissolution and Precipitation of Supersaturating Formulations
|
|---|---|
| Published in |
The AAPS Journal, September 2015
|
| DOI | 10.1208/s12248-015-9825-6 |
| Pubmed ID | |
| Authors |
Dajun D. Sun, Ping I. Lee |
| Abstract |
Contrary to the early philosophy of supersaturating formulation design for oral solid dosage forms, current evidence shows that an exceedingly high rate of supersaturation generation could result in a suboptimal in vitro dissolution profile and subsequently could reduce the in vivo oral bioavailability of amorphous solid dispersions. In this commentary, we outline recent research efforts on the specific effects of the rate and extent of supersaturation generation on the overall kinetic solubility profiles of supersaturating formulations. Additional insights into an appropriate definition of sink versus nonsink dissolution conditions and the solubility advantage of amorphous pharmaceuticals are also highlighted. The interplay between dissolution and precipitation kinetics should be carefully considered in designing a suitable supersaturating formulation to best improve the dissolution behavior and oral bioavailability of poorly water-soluble drugs. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 123 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 123 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 25 | 20% |
| Researcher | 20 | 16% |
| Student > Master | 17 | 14% |
| Student > Bachelor | 11 | 9% |
| Student > Doctoral Student | 9 | 7% |
| Other | 17 | 14% |
| Unknown | 24 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Pharmacology, Toxicology and Pharmaceutical Science | 48 | 39% |
| Chemistry | 11 | 9% |
| Agricultural and Biological Sciences | 7 | 6% |
| Medicine and Dentistry | 7 | 6% |
| Engineering | 4 | 3% |
| Other | 14 | 11% |
| Unknown | 32 | 26% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 September 2015.
All research outputs
#18,427,608
of 22,829,083 outputs
Outputs from The AAPS Journal
#1,101
of 1,287 outputs
Outputs of similar age
#192,515
of 266,943 outputs
Outputs of similar age from The AAPS Journal
#21
of 27 outputs
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We're also able to compare this research output to 27 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.