| Title |
Tailored exercise interventions to reduce fatigue in cancer survivors: study protocol of a randomized controlled trial
|
|---|---|
| Published in |
BMC Cancer, July 2018
|
| DOI | 10.1186/s12885-018-4668-z |
| Pubmed ID | |
| Authors |
Rosie Twomey, Tristan Martin, John Temesi, S. Nicole Culos-Reed, Guillaume Y. Millet |
| Abstract |
Cancer-related fatigue (CRF) is a common and distressing symptom of cancer and/or cancer treatment that persists for years after treatment completion in approximately one third of cancer survivors. Exercise is beneficial for the management of CRF, and general exercise guidelines for cancer survivors are available. There are multiple potential pathways by which exercise improves CRF, and cancer survivors with CRF are diverse with respect to cancer type, treatments and experienced side effects. While the general exercise guidelines are likely sufficient for most cancer survivors, tailoring of exercise interventions may be more effective in those with persistent fatigue. The primary aim of this research is to investigate the effect of a traditional vs. tailored exercise intervention on CRF severity in cancer survivors with persistent CRF. Cancer survivors (≥ 3 months and ≤ 5 years since primary treatment) who score ≤ 34 on the Functional Assessment of Chronic Illness Therapy Fatigue Scale (FACIT-F) will be randomly allocated to one of two parallel treatment arms: traditional (active control) and tailored exercise. Participants in the traditional exercise group will engage in aerobic and resistance exercise that is consistent with exercise guidelines for cancer survivors. The tailored exercise group will be prescribed an intervention designed to address individual deficits identified at baseline, such as loss of muscular strength, cardiorespiratory deconditioning or sleep disturbance. Participants will be assessed before and after the intervention for CRF severity and other patient-reported outcomes, neuromuscular function and fatigue in response to whole-body exercise, sleep quantity and quality, physical activity levels, cardiorespiratory fitness and blood biomarkers. To our knowledge, this will be the first study to compare the effects of a traditional vs. tailored exercise intervention on CRF severity in cancer survivors with persistent CRF. Using physiological, behavioural and patient-reported outcomes, this study will add to the current knowledge about both the factors contributing to CRF, and the potential reduction in CRF severity with an exercise intervention. The study is registered at ClinicalTrials.gov ( NCT03049384 ), February, 2017. |
X Demographics
The data shown below were collected from the profiles of 47 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 13 | 28% |
| Canada | 3 | 6% |
| Australia | 3 | 6% |
| Spain | 2 | 4% |
| Ireland | 1 | 2% |
| Jersey | 1 | 2% |
| United States | 1 | 2% |
| Unknown | 23 | 49% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 30 | 64% |
| Practitioners (doctors, other healthcare professionals) | 8 | 17% |
| Scientists | 8 | 17% |
| Science communicators (journalists, bloggers, editors) | 1 | 2% |
Mendeley readers
The data shown below were compiled from readership statistics for 194 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 194 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 37 | 19% |
| Student > Bachelor | 27 | 14% |
| Student > Ph. D. Student | 19 | 10% |
| Researcher | 15 | 8% |
| Student > Postgraduate | 11 | 6% |
| Other | 29 | 15% |
| Unknown | 56 | 29% |
| Readers by discipline | Count | As % |
|---|---|---|
| Nursing and Health Professions | 43 | 22% |
| Sports and Recreations | 26 | 13% |
| Medicine and Dentistry | 23 | 12% |
| Psychology | 7 | 4% |
| Neuroscience | 4 | 2% |
| Other | 22 | 11% |
| Unknown | 69 | 36% |
Attention Score in Context
This research output has an Altmetric Attention Score of 31. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 May 2019.
All research outputs
#1,221,807
of 24,535,155 outputs
Outputs from BMC Cancer
#159
of 8,711 outputs
Outputs of similar age
#26,348
of 334,419 outputs
Outputs of similar age from BMC Cancer
#3
of 135 outputs
Altmetric has tracked 24,535,155 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 8,711 research outputs from this source. They receive a mean Attention Score of 4.5. This one has done particularly well, scoring higher than 98% of its peers.
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We're also able to compare this research output to 135 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 98% of its contemporaries.