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Aicardi-Goutières Syndrome Gene and HIV-1 Restriction Factor SAMHD1 Is a dGTP-regulated Deoxynucleotide Triphosphohydrolase* ♦

Overview of attention for article published in Journal of Biological Chemistry, November 2011
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (80th percentile)
  • High Attention Score compared to outputs of the same age and source (82nd percentile)

Mentioned by

patent
1 patent
facebook
1 Facebook page
wikipedia
1 Wikipedia page

Citations

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302 Dimensions

Readers on

mendeley
144 Mendeley
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Title
Aicardi-Goutières Syndrome Gene and HIV-1 Restriction Factor SAMHD1 Is a dGTP-regulated Deoxynucleotide Triphosphohydrolase* ♦
Published in
Journal of Biological Chemistry, November 2011
DOI 10.1074/jbc.c111.317628
Pubmed ID
Authors

Rebecca D Powell, Paul J Holland, Thomas Hollis, Fred W Perrino

Abstract

The SAMHD1 protein is an HIV-1 restriction factor that is targeted by the HIV-2 accessory protein Vpx in myeloid lineage cells. Mutations in the SAMHD1 gene cause Aicardi-Goutières syndrome, a genetic disease that mimics congenital viral infection. To determine the physiological function of the SAMHD1 protein, the SAMHD1 gene was cloned, recombinant protein was produced, and the catalytic activity of the purified enzyme was identified. We show that SAMHD1 contains a dGTP-regulated deoxynucleotide triphosphohydrolase. We propose that Vpx targets SAMHD1 for degradation in a viral strategy to control cellular deoxynucleotide levels for efficient replication.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 144 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 3 2%
United Kingdom 2 1%
Switzerland 1 <1%
Canada 1 <1%
Germany 1 <1%
Unknown 136 94%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 42 29%
Researcher 34 24%
Student > Master 13 9%
Student > Bachelor 10 7%
Professor > Associate Professor 9 6%
Other 21 15%
Unknown 15 10%
Readers by discipline Count As %
Agricultural and Biological Sciences 53 37%
Biochemistry, Genetics and Molecular Biology 34 24%
Medicine and Dentistry 19 13%
Immunology and Microbiology 11 8%
Chemistry 2 1%
Other 7 5%
Unknown 18 13%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 November 2014.
All research outputs
#5,339,368
of 25,374,647 outputs
Outputs from Journal of Biological Chemistry
#13,638
of 85,241 outputs
Outputs of similar age
#30,524
of 154,561 outputs
Outputs of similar age from Journal of Biological Chemistry
#81
of 471 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. Compared to these this one has done well and is in the 78th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 85,241 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.1. This one has done well, scoring higher than 83% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 154,561 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 80% of its contemporaries.
We're also able to compare this research output to 471 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 82% of its contemporaries.