Title |
Yeast Model of Amyloid-β and Tau Aggregation in Alzheimer’s Disease
|
---|---|
Published in |
Journal of Alzheimer's Disease, January 2015
|
DOI | 10.3233/jad-150173 |
Pubmed ID | |
Authors |
Behrooz Moosavi, Bibimaryam Mousavi, Ian G Macreadie |
Abstract |
The amyloid-β peptide (Aβ) and the phosphorylated protein tau have been widely implicated in Alzheimer's disease and are the focus of most research. Both agents have been extensively studied in mammalian cell culture and in animal studies, but new research is focusing on yeast models. Yeast are eukaryotes, just like us, and are amenable to effects and expression of Aβ and tau and appear able to 'report' with considerable relevance on the effects of these biomolecules. The use of yeast enables powerful new approaches to understanding how to overcome the effects of Aβ and tau, and such advances could lead to new therapies to prevent the progression of Alzheimer's disease. |
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France | 1 | 100% |
Demographic breakdown
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Members of the public | 1 | 100% |
Mendeley readers
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Unknown | 36 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 9 | 24% |
Student > Master | 9 | 24% |
Student > Ph. D. Student | 7 | 19% |
Student > Bachelor | 3 | 8% |
Student > Doctoral Student | 1 | 3% |
Other | 1 | 3% |
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Medicine and Dentistry | 2 | 5% |
Other | 6 | 16% |
Unknown | 7 | 19% |